Investigating hepatic p53-mediated neutrophil suppression in non-alcoholic steatohepatitis

Project Details


To characterise how the dynamics of p53 signalling relate to neutrophil infiltration,
NET formation, and disease progression in diet-induced NASH-T2DM
2. To determine mechanisms that underpin neutrophil-suppressive p53 activity in NASHT2DM
3. To examine the efficacy of neutrophil and NET-targeted therapies in preventing dietinduced NASH-T2DM
Short titlep53-neutrophils-NASH
StatusNot started


  • Medical Research Council: £840,557.00

UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This project contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being


Explore the research topics touched on by this project. These labels are generated based on the underlying awards/grants. Together they form a unique fingerprint.