Investigate retinal cholesterol homeostatis in an Alzheimer's disease mouse model

Alzheimers Disease (AD) is the most common cause of dementia and is a growing global health concern, affecting 850,000 in the UK. AD is characterised by a spectrum of cognitive and neuropsychiatric symptoms, including severe memory loss, behavioural changes, disorientation, visual impairments,sleep disturbances, and at late stages: difficulties in walking and swallowing and invariably death. Abnormal accumulation of amyloid beta in the retina of AD patients may contribute to visual function defects and this and the underlying biological causes shall be the focus of this study.