Effects of macitentan on non invasive myocardial tissue characterisation by cardiac MRI in a sugen/hypoxia rat model of pulmonary arterial hypertension.

Project Details

Description

A reversal strategy of disease using the most up to date current therapy, macitentan, would be utilised using the most relevant contemporary model of PH, the SUGEN / hypoxia model. This will be the first study to correlate non-invasive myocardial tissue characterisation by means of T1 mapping with histological analysis in subjects with pulmonary hypertension using a disease targeted therapy.
StatusActive
Effective start/end date1/06/1931/12/22

Funding

  • Actelion Pharmaceuticals UK Ltd: £38,469.00

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