Effects of macitentan on non invasive myocardial tissue characterisation by cardiac MRI in a sugen/hypoxia rat model of pulmonary arterial hypertension.

A reversal strategy of disease using the most up to date current therapy, macitentan, would be utilised using the most relevant contemporary model of PH, the SUGEN / hypoxia model. This will be the first study to correlate non-invasive myocardial tissue characterisation by means of T1 mapping with histological analysis in subjects with pulmonary hypertension using a disease targeted therapy.