Tim Humpton

Emailthu2gcu.acuk

70 Cowcaddens Road, Glasgow Caledonian University
G4 0BA Glasgow
United Kingdom

Accepting PhD Students

PhD projects

Investigating hepatic p53-mediated neutrophil suppression in non-alcoholic steatohepatitis

Targeting cancer pathways in metabolic syndrome to prevent liver cancer

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Research activity per year

11 Article
1 Review article
1 Preprint

11 results

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2024
The role of APOBEC3B in lung tumor evolution and targeted cancer therapy resistance
Caswell, D. R., Gui, P., Mayekar, M. K., Law, E. K., Pich, O., Bailey, C., Boumelha, J., Kerr, D. L., Blakely, C. M., Manabe, T., Martinez-Ruiz, C., Bakker, B., De Dios Palomino Villcas, J., I. Vokes, N., Dietzen, M., Angelova, M., Gini, B., Tamaki, W., Allegakoen, P. & Wu, W. & 65 others, Humpton, T. J., Hill, W., Tomaschko, M., Lu, W. T., Haderk, F., Al Bakir, M., Nagano, A., Gimeno-Valiente, F., de Carné Trécesson, S., Vendramin, R., Barbè, V., Mugabo, M., Weeden, C. E., Rowan, A., McCoach, C. E., Almeida, B., Green, M., Gomez, C., Nanjo, S., Barbosa, D., Moore, C., Przewrocka, J., Black, J. R. M., Grönroos, E., Suarez-Bonnet, A., Priestnall, S. L., Zverev, C., Lighterness, S., Cormack, J., Olivas, V., Cech, L., Andrews, T., Rule, B., Jiao, Y., Zhang, X., Ashford, P., Durfee, C., Venkatesan, S., Temiz, N. A., Tan, L., Larson, L. K., Argyris, P. P., Brown, W. L., Yu, E. A., Rotow, J. K., Guha, U., Roper, N., Yu, J., Vogel, R. I., Thomas, N. J., Marra, A., Selenica, P., Yu, H., Bakhoum, S. F., Chew, S. K., Reis-Filho, J. S., Jamal-Hanjani, M., Vousden, K. H., McGranahan, N., Van Allen, E. M., Kanu, N., Harris, R. S., Downward, J., Bivona, T. G. & Swanton, C., Jan 2024, In: Nature Genetics. 56, 1, p. 60-73 14 p.
Research output: Contribution to journal › Article › peer-review

Open Access
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32 Citations (Scopus)

69 Downloads (Pure)
2022
A noninvasive iRFP713 p53 reporter reveals dynamic p53 activity in response to irradiation and liver regeneration in vivo
Humpton, T. J., Hock, A. K., Kiourtis, C., De Donatis, M., Fercoq, F., Nixon, C., Bryson, S., Strathdee, D., Carlin, L. M., Bird, T. G., Blyth, K. & Vousden, K. H., 8 Feb 2022, In: Science Signaling. 15, 720, eabd9099.
Research output: Contribution to journal › Article › peer-review

Open Access
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4 Citations (Scopus)

38 Downloads (Pure)
p53-mediated redox control promotes liver regeneration and maintains liver function in response to CCl₄
Humpton, T. J., Hall, H., Kiourtis, C., Nixon, C., Clark, W., Hedley, A., Shaw, R., Bird, T. G., Blyth, K. & Vousden, K. H., Mar 2022, In: Cell Death and Differentiation. 29, p. 514-526 13 p.
Research output: Contribution to journal › Article › peer-review

Open Access
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22 Citations (Scopus)

78 Downloads (Pure)
2021
Differential requirements for MDM2 E3 activity during embryogenesis and in adult mice
Humpton, T. J., Nomura, K., Weber, J., Magnussen, H. M., Hock, A. K., Nixon, C., Dhayade, S., Stevenson, D., Huang, D. T., Strathdee, D., Blyth, K. & Vousden, K. H., 2021, In: Genes and Development. 35, p. 117-132 16 p.
Research output: Contribution to journal › Article › peer-review

Open Access
File
8 Citations (Scopus)

45 Downloads (Pure)
2019
Oncogenic KRAS induces NIX-mediated mitophagy to promote pancreatic cancer
Humpton, T. J., Alagesan, B., DeNicola, G. M., Lu, D., Yordanov, G. N., Leonhardt, C. S., Yao, M. A., Alagesan, P., Zaatari, M. N., Park, Y., Skepper, J. N., Macleod, K. F., Perez-Mancera, P. A., Murphy, M. P., Evan, G. I., Vousden, K. H. & Tuveson, D. A., 1 Sept 2019, In: Cancer Discovery. 9, 9, p. 1268-1287 20 p.
Research output: Contribution to journal › Article › peer-review
138 Citations (Scopus)
2018
A role for p53 in the adaptation to glutamine starvation through the expression of SLC1A3
Tajan, M., Hock, A. K., Blagih, J., Robertson, N. A., Labuschagne, C. F., Kruiswijk, F., Humpton, T. J., Adams, P. D. & Vousden, K. H., 6 Nov 2018, In: Cell Metabolism. 28, 5, p. 721-736. E6 23 p.
Research output: Contribution to journal › Article › peer-review

Open Access
File
181 Citations (Scopus)

45 Downloads (Pure)
2017
Development of an inducible mouse model of iRFP713 to track recombinase activity and tumour development in vivo
Hock, A. K., Cheung, E. C., Humpton, T. J., Monteverde, T., Paulus-Hock, V., Lee, P., McGhee, E., Scopelliti, A., Murphy, D. J., Strathdee, D., Blyth, K. & Vousden, K. H., 12 May 2017, In: Scientific Reports. 7, 1837.
Research output: Contribution to journal › Article › peer-review

Open Access
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17 Citations (Scopus)

13 Downloads (Pure)
2016
Regulation of cellular metabolism and hypoxia by p53
Humpton, T. J. & Vousden, K. H., Jul 2016, In: Cold Spring Harbor Perspectives in Medicine. 6, 7, 21 p., a026146.
Research output: Contribution to journal › Article › peer-review
113 Citations (Scopus)
2011
Aneuploidy drives genomic instability in yeast
Sheltzer, J. M., Blank, H. M., Pfau, S. J., Tange, Y., George, B. M., Humpton, T. J., Brito, I. L., Hiraoka, Y., Niwa, O. & Amon, A., 19 Aug 2011, In: Science. 333, 6045, p. 1026-1030 5 p.
Research output: Contribution to journal › Article › peer-review
319 Citations (Scopus)
Caspase-2-Mediated Cleavage of Mdm2 Creates a p53-Induced Positive Feedback Loop
Oliver, T. G., Meylan, E., Chang, G. P., Xue, W., Burke, J. R., Humpton, T. J., Hubbard, D., Bhutkar, A. & Jacks, T., 8 Jul 2011, In: Molecular Cell. 43, 1, p. 57-71 15 p.
Research output: Contribution to journal › Article › peer-review

Open Access
128 Citations (Scopus)
Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis
DeNicola, G. M., Karreth, F. A., Humpton, T. J., Gopinathan, A., Wei, C., Frese, K., Mangal, D., Yu, K. H., Yeo, C. J., Calhoun, E. S., Scrimieri, F., Winter, J. M., Hruban, R. H., Iacobuzio-Donahue, C., Kern, S. E., Blair, I. A. & Tuveson, D. A., 6 Jul 2011, In: Nature. 475, p. 106-109 4 p.
Research output: Contribution to journal › Article › peer-review
1869 Citations (Scopus)

Tim Humpton

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