Tim Humpton

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Tim Humpton

Dr.

 https://orcid.org/0000-0002-8030-9539

  • 70 Cowcaddens Road, Glasgow Caledonian University

    G4 0BA Glasgow

    United Kingdom

Accepting PhD Students

PhD projects

Investigating hepatic p53-mediated neutrophil suppression in non-alcoholic steatohepatitis

Targeting cancer pathways in metabolic syndrome to prevent liver cancer

Calculated based on number of publications stored in Pure and citations from Scopus
20112024

Research activity per year

Personal profile

Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being

Education/Academic qualification

PhD, Biochemistry, Oncogenic KRAS stimulates the clearance of functional mitochondria to promote proliferation during glucose deprivation, University of Cambridge

1 Oct 2010 → 31 May 2014

Award Date: 1 Jul 2014

SB, Biology, Massachusetts Institute of Technology

1 Sept 2006 → 31 May 2010

Award Date: 5 Jun 2010

SB, Chemical-Biological Engineering, Massachusetts Institute of Technology

1 Sept 2006 → 31 May 2010

Award Date: 5 Jun 2010

Keywords

  • Disease Modelling
  • GEMMs
  • Cancer Biology
  • p53
  • HCC
  • NASH
  • Molecular Biology
  • Cell Biology
  • mitophagy
  • ROS

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Collaborations and top research areas from the last five years

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  • p53 and TIGAR promote redox control to protect against metabolic dysfunction-associated steatohepatitis

    Wittke, C. I., Cheung, E. C., Athineos, D., Clements, N., Butler, L., Hughes, M., Morrison, V., Watt, D. M., Blyth, K., Vousden, K. H. & Humpton, T. J., 21 May 2024, Cold Spring Harbor Laboratory Press, 29 p. (bioRxiv ).

    Research output: Working paper › Preprint

    Open Access
    File
    11 Downloads (Pure)

  • The role of APOBEC3B in lung tumor evolution and targeted cancer therapy resistance

    Caswell, D. R., Gui, P., Mayekar, M. K., Law, E. K., Pich, O., Bailey, C., Boumelha, J., Kerr, D. L., Blakely, C. M., Manabe, T., Martinez-Ruiz, C., Bakker, B., De Dios Palomino Villcas, J., I. Vokes, N., Dietzen, M., Angelova, M., Gini, B., Tamaki, W., Allegakoen, P. & Wu, W. & 65 others, Humpton, T. J., Hill, W., Tomaschko, M., Lu, W. T., Haderk, F., Al Bakir, M., Nagano, A., Gimeno-Valiente, F., de Carné Trécesson, S., Vendramin, R., Barbè, V., Mugabo, M., Weeden, C. E., Rowan, A., McCoach, C. E., Almeida, B., Green, M., Gomez, C., Nanjo, S., Barbosa, D., Moore, C., Przewrocka, J., Black, J. R. M., Grönroos, E., Suarez-Bonnet, A., Priestnall, S. L., Zverev, C., Lighterness, S., Cormack, J., Olivas, V., Cech, L., Andrews, T., Rule, B., Jiao, Y., Zhang, X., Ashford, P., Durfee, C., Venkatesan, S., Temiz, N. A., Tan, L., Larson, L. K., Argyris, P. P., Brown, W. L., Yu, E. A., Rotow, J. K., Guha, U., Roper, N., Yu, J., Vogel, R. I., Thomas, N. J., Marra, A., Selenica, P., Yu, H., Bakhoum, S. F., Chew, S. K., Reis-Filho, J. S., Jamal-Hanjani, M., Vousden, K. H., McGranahan, N., Van Allen, E. M., Kanu, N., Harris, R. S., Downward, J., Bivona, T. G. & Swanton, C., Jan 2024, In: Nature Genetics. 56, p. 60-73 14 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    File
    26 Citations (Scopus)
    65 Downloads (Pure)

  • A noninvasive iRFP713 p53 reporter reveals dynamic p53 activity in response to irradiation and liver regeneration in vivo

    Humpton, T. J., Hock, A. K., Kiourtis, C., De Donatis, M., Fercoq, F., Nixon, C., Bryson, S., Strathdee, D., Carlin, L. M., Bird, T. G., Blyth, K. & Vousden, K. H., 8 Feb 2022, In: Science Signaling. 15, 720, eabd9099.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    File
    4 Citations (Scopus)
    38 Downloads (Pure)

  • p53-mediated redox control promotes liver regeneration and maintains liver function in response to CCl4

    Humpton, T. J., Hall, H., Kiourtis, C., Nixon, C., Clark, W., Hedley, A., Shaw, R., Bird, T. G., Blyth, K. & Vousden, K. H., Mar 2022, In: Cell Death and Differentiation. 29, p. 514-526 13 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    File
    20 Citations (Scopus)
    78 Downloads (Pure)

  • Differential requirements for MDM2 E3 activity during embryogenesis and in adult mice

    Humpton, T. J., Nomura, K., Weber, J., Magnussen, H. M., Hock, A. K., Nixon, C., Dhayade, S., Stevenson, D., Huang, D. T., Strathdee, D., Blyth, K. & Vousden, K. H., 2021, In: Genes and Development. 35, p. 117-132 16 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    File
    8 Citations (Scopus)
    45 Downloads (Pure)
View all 13 research outputs
  • 2 Types of Public engagement and outreach - Schools engagement