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Paul Baker

Dr.

  • 70 Cowcaddens Road, Glasgow Caledonian University

    G4 0BA Glasgow

    United Kingdom

20092016
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Personal profile

Research interests

Zoonoses: the source of the next Emerging Infectious Disease

 

Zoonoses are diseases that can be transmitted from animals to humans, and have been the source of many of the pandemics that have devastated human populations throughout history 1,2. To prevent new emerging infectious diseases it is essential to identify the pathogens (e.g. viruses, bacteria or protozoans) that are currently circulating in the populations of animals that we are in contact with, including pets, farm animals and wildlife.

Ticks are a vector for many diseases worldwide, and in the UK tick numbers are on the increase. In Europe, the number of diseases that we can contract from them is also growing, for example the geographical distribution of tick-borne encephalitis and Crimean-Congo haemorrhagic fever virus are changing and are now endemic in eastern and some parts of southern Europe3.

Here in the UK cases of Lyme disease4, caused by the spirochaete bacteria Borrelia burgdorferi and transmitted to humans through bites of the Ixodes genus of tick are increasing, and a closely related species Borrelia myamotoi5 has recently been found in ticks in southern England. It is not only humans that are at risk of new infections, Babeosis canis a protozoan of dogs has also been reported in Essex in England, these are the first cases in the UK found in dogs that have never been abroad6.

By analysing the ticks present on pets and on other animals such as hedgehogs7 that are in close contact or interact with people, identifying, the species of the ticks, the bacteria, the viruses, the protozoans, and the animals the ticks have previously fed on, we can have a better chance of predicting the sources of future infections, and the risk to human health8, 9.

Ticks can also be transported while feeding on migratory birds to the UK from as far away as Africa and eastern Siberia and therefor are a possible source of new viral and bacterial pathogens that may cause human disease10.

Which species are hosting these vectors, how prevalent are the pathogens and, at what levels?

 

Using molecular biology techniques such as PCR, qPCR Cloning sequencing and bioinformatics I am interested in designing and developing assays to identify these newly arrived pathogens, and the hosts and vectors involved in their propagation.

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  • 4 Similar Profiles
Smegmamorpha Medicine & Life Sciences
Hepatitis E virus Medicine & Life Sciences
Shellfish Medicine & Life Sciences
Metabolomics Medicine & Life Sciences
Gasterosteus aculeatus Agriculture & Biology
Gasterosteidae Agriculture & Biology
metabolomics Agriculture & Biology
Ticks Medicine & Life Sciences

Research Output 2009 2016

Selective CD28 antagonist blunts memory immune responses and promotes long-term control of skin inflammation in nonhuman primates

Poirier, N., Chevalier, M., Mary, C., Hervouet, J., Minault, D., Baker, P., Ville, S., Le Bas-Bernardet, S., Dilek, N., Belarif, L., Cassagnau, E., Scobie, L., Blancho, G. & Vanhove, B., 1 Jan 2016, In : Journal of Immunology. 196, 1, p. 274-283 10 p.

Research output: Contribution to journalArticle

Primates
Inflammation
T-Lymphocytes
Skin
Lymphocyte Count

Correction: selective blockade of CD28-mediated T cell costimulation protects rhesus monkeys against acute fatal experimental autoimmune encephalomyelitis

Haanstra, K. G., Dijkman, K., Bashir, N., Bauer, J., Mary, C., Poirier, N., Baker, P., Crossan, C., Scobie, L., 't Hart, B. A. & Vanhove, B., 15 Jul 2015, In : Journal of Immunology. 195, 2

Research output: Contribution to journalArticle

Hepatitis E virus genotype 3 in shellfish, United Kingdom

Crossan, C., Baker, P., Craft, J., Yasu, T., Dalton, H. & Scobie, L., Dec 2012, In : Emerging Infectious Diseases. 18, 12, p. 2085-2087 2 p.

Research output: Contribution to journalLetter

Hepatitis E virus
Shellfish
Manure
Bivalvia
Genotype

Hepatic transcriptomic and metabolomic responses in the Stickleback (Gasterosteus aculeatus) exposed to ethinyl-estradiolstar

Katsiadaki, I., Williams, T., Ball, J., Bean, T., Sanders, M., Wu, H., Santos, E., Brown, M., Baker, P. & Craft, J. A., 1 May 2010, In : Aquatic Toxicology. 97, 3, p. 174-187 14 p.

Research output: Contribution to journalArticle

Smegmamorpha
Metabolomics
Gasterosteus aculeatus
Gasterosteidae
metabolomics

Hepatic transcriptomic and metabolomic responses in the stickleback (Gasterosteus aculeatus) exposed to environmentally-relevant concentrations of dibenzanthracene

Williams, T., Wu, H., Santos, E., Ball, J., Katsiadaki, I., Brown, M., Baker, P., Ortago, F. & Craft, J. A., 1 Jul 2009, In : Environmental Science and Technology. 43, 16, p. 6341-6348 8 p.

Research output: Contribution to journalArticle

Cytochrome P-450 Enzyme System
cytochrome
Polycyclic Aromatic Hydrocarbons
Biomarkers
Metabolites