Projects per year
Personal profile
Research interests
I am a newly appointed lecturer currently developing an independent research group. I have acquired extensive experience in the design, delivery and assessment of teaching and learning activities undertaken by biomedical science students both in China and Scotland.
I have over 12 years of expertise in researching blood cancers, including Acute Lymphoblastic Leukaemia and Mutliple Myeloma, and have identified new potentially targetable disease mechanisms. Currently, the leukemia field is shifting from a leukemic cell-centered research perspective to a view in which the environment within the bone marrow (BMME) is considered increasingly important in shielding leukemic cells from chemotherapy drugs (chemoresistance). Strategies thus far for modeling and targeting leukaemia – BMME cross-talk, however are currently inadequate. My independent research is focusing on using a unique 3D co-culture system for better modelling and targeting of BMME-mediated chemoresistance mechanisms in AML. This research has the potential to discover novel targetable mechanisms of disease in AML and other blood cancers. I am performing clinically relevant research studies, by collaborating with key academic (e.g. Dr Monica L Guzman - Cornell University, USA & Professor Mhairir Copland - University of Glasgow UK) and industrial (e.g. Dr Simon T Barry - AstraZeneca & Dr Sheelagh - Cyclacel, UK) researchers. This research could lead to improved clinical outcomes in blood cancer patients, such as survival and quality of life.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Collaborations and top research areas from the last five years
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Generating a Novel High-Affinity Multi-Targeting Therapeutic Antibody for Multiple Myeloma
Williams, M. (PI), Mulheran, P. (CoI) & Wagner, E. (CoI)
Project: Studentship
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MACRESIST: Investigating immune cell “macrophage” driven drug resistance in Acute Myeloid Leukaemia
Williams, M. (PI)
Project: Research Grant
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Development of a novel platform lipid nanoparticle system to induce tailored immune responses for therapeutic benefit
Williams, M. (PI), Kelemen, D. (CoI), Schijns, V. (CoI), Ferro, V. (CoI) & Mulheran, P. (PI)
Project: Studentship
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Generating a novel high-affinity multi-targeting therapeutic antibody for Multiple Myeloma
Williams, M. (PI) & Wagner, E. (CoI)
Project: Knowledge Exchange
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Cancer microenvironment and pharmacological interventions
Williams, M. T. S. & Guzman, M. L., Jan 2024, In: British Journal of Pharmacology. 181, 2, p. 213-215 3 p.Research output: Contribution to journal › Editorial › peer-review
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IL-10R inhibition reprograms tumor-associated macrophages and reverses drug resistance in multiple myeloma
Sun, J., Corradini, S., Azab, F., Shokeen, M., Muz, B., Miari, K. E., Maksimos, M., Diedrich, C., Asare, O., Alhallak, K., Park, C., Lubben, B., Chen, Y., Adebayo, O., Bash, H., Kelley, S., Fiala, M., Bender, D. E., Zhou, H. & Wang, S. & 3 others, , 30 Aug 2024, (E-pub ahead of print) In: Leukemia. 11 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile4 Downloads (Pure) -
PV powered modular pulse generator with embedded energy storage for tumour treating fields
Alshahat, M. A., Elgenedy, M. A., Aboushady, A. A., Williams, M., Nazir, S., Elmrabit, N. & Larijani, H., 6 Jun 2024, (Accepted/In press) Proceedings of 59th International Universities Power Engineering Conference. IEEEResearch output: Chapter in Book/Report/Conference proceeding › Conference contribution
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Stromal bone marrow fibroblasts and mesenchymal stem cells support acute myeloid leukaemia cells and promote therapy resistance
Miari, K. E. & Williams, M. T. S., Jan 2024, In: British Journal of Pharmacology. 181, 2, p. 216-237 22 p.Research output: Contribution to journal › Review article › peer-review
Open AccessFile8 Citations (Scopus)151 Downloads (Pure) -
The splicing factor Prpf31 is required for hematopoietic stem and progenitor cell expansion during zebrafish embryogenesis
Lv, Y., Li, J., Yu, S., Zhang, Y., Hu, H., Sun, K., Jia, D., Han, Y., Tu, J., Huang, Y., Liu, X., Zhang, X., Gao, P., Chen, X., Williams, M. T. S., Tang, Z., Shu, X., Liu, M. & Ren, X., Mar 2024, In: Journal of Biological Chemistry. 300, 3, 15 p., 105772.Research output: Contribution to journal › Article › peer-review
Open AccessFile14 Downloads (Pure)