Photo of Mark Williams
  • 70 Cowcaddens Road, Glasgow Caledonian University

    G4 0BA Glasgow

    United Kingdom

20082016
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Personal profile

Research interests

I am a newly appointed lecturer currently developing an independent research group. I have acquired extensive experience in the design, delivery and assessment of teaching and learning activities undertaken by biomedical science students both in China and Scotland.

I have over 7 years of expertise in researching blood cancers, including Acute Lymphoblastic Leukaemia and Mutliple Myeloma, and have identified new potentially targetable disease mechanisms. Currently, the leukemia field is shifting from a leukemic cell-centered research perspective to a view in which the environment within the bone marrow (BMME) is considered increasingly important in shielding leukemic cells from chemotherapy drugs (chemoresistance). Strategies thus far for modeling and targeting leukaemia – BMME cross-talk, however are currently inadequate. My independent research is focusing on using a unique 3D co-culture system for better modelling and targeting of BMME-mediated chemoresistance mechanisms in AML. This research has the potential to discover novel targetable mechanisms of disease in AML and other blood cancers. I am performing clinically relevant research studies, by collaborating with key academic (e.g. Dr Monica L Guzman - Conrell University, USA & Professor Mhairir Copland - University of Glasgow UK) and industrial (e.g. Dr Simon T Barry - AstraZeneca & Dr Sheelagh - Cyclacel, UK) researchers. This research could lead to improved clinical outcomes in blood cancer patients, such as survival and quality of life.

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Cystic Fibrosis Medicine & Life Sciences
Precursor Cell Lymphoblastic Leukemia-Lymphoma Medicine & Life Sciences
Epithelial Cells Medicine & Life Sciences
Central Nervous System Medicine & Life Sciences
Nose Medicine & Life Sciences
Neurology Chemical Compounds
Cell Line Medicine & Life Sciences
Interleukin-15 Medicine & Life Sciences

Research Output 2008 2016

Bronchial epithelial cell lines and primary nasal epithelial cells from cystic fibrosis respond differently to cigarette smoke exposure

Williams, M., de Courcey, F., Comer, D., Elborn, JS. & Ennis, M., 1 Jul 2016, In : Journal of Cystic Fibrosis. 15, 4, p. 467-472 6 p.

Research output: Contribution to journalArticle

Nose
Cystic Fibrosis
Smoke
Tobacco Products
Epithelial Cells

The ability to cross the blood-cerebrospinal fluid barrier is a generic property of acute lymphoblastic leukemia blasts

Williams, M., Yousafzai, Y., Elder, A., Rehe, K., Bomken, S., Frishman-Levy, L., Tavor, S., Sinclair, P., Dormon, K., Masic, D., Perry, T., Weston, VJ., Kearns, P., Russell, LJ., Heidenreich, O., Irving, JA., Izraeli, S., Vormoor, J., Graham, GJ. & Halsey, C., 21 Apr 2016, In : Blood. 127, 16, p. 1998-2006 9 p.

Research output: Contribution to journalArticle

Cerebrospinal fluid
Neurology
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Cerebrospinal Fluid
Blood

Targeting of Fc receptors reduces bone disease in a pre-clinical model of multiple myeloma

Williams, M., Thuemmler, K., Kitson, S., Soutar, R. & Goodyear, C., 6 Dec 2015, In : Blood. 126, p. 3011 1 p.

Research output: Contribution to journalArticle

Fc Receptors
Bone Diseases
Multiple Myeloma
Bone
Osteoclasts

Interleukin-15 enhances cellular proliferation and up-regulates CNS homing molecules in pre-B acute lymphoblastic leukemia

Williams, M., Yousafzai, Y., Cox, C., Blair, A., Carmody, R., Sai, S., Chapman, KE., McAndrew, R., Thomas, A., Spence, A., Gibson, B., Graham, GJ. & Halsey, C., 15 May 2014, In : Blood. 123, 20, p. 3116-3127 12 p.

Research output: Contribution to journalArticle

Interleukin-15
Neurology
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Up-Regulation
Central Nervous System

An analysis of mechanisms of central nervous system infiltration in acute lymphoblastic leukaemia using primary cells xenografted into immunodeficient mice

Yousafzai, Y., Williams, M., Rehe, K., Le Brocq, M., Bomken, S., Sinclair, P., Dormon, K., Masic, D., Archer, L., Watt, J., Perry, T., Weston, V., Kearns, P., Blair, H., Russel, L., Heidenreich, O., Irving, J., Vormoor, J., Gibson, B., Graham, G. & 1 others, Halsey, C., 5 Dec 2013, In : Blood. 122, 21, p. 3899 1 p.

Research output: Contribution to journalArticle

Neurology
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Infiltration
Central Nervous System
Chemokine Receptors