Projects per year
I am a newly appointed lecturer currently developing an independent research group. I have acquired extensive experience in the design, delivery and assessment of teaching and learning activities undertaken by biomedical science students both in China and Scotland.
I have over 12 years of expertise in researching blood cancers, including Acute Lymphoblastic Leukaemia and Mutliple Myeloma, and have identified new potentially targetable disease mechanisms. Currently, the leukemia field is shifting from a leukemic cell-centered research perspective to a view in which the environment within the bone marrow (BMME) is considered increasingly important in shielding leukemic cells from chemotherapy drugs (chemoresistance). Strategies thus far for modeling and targeting leukaemia – BMME cross-talk, however are currently inadequate. My independent research is focusing on using a unique 3D co-culture system for better modelling and targeting of BMME-mediated chemoresistance mechanisms in AML. This research has the potential to discover novel targetable mechanisms of disease in AML and other blood cancers. I am performing clinically relevant research studies, by collaborating with key academic (e.g. Dr Monica L Guzman - Cornell University, USA & Professor Mhairir Copland - University of Glasgow UK) and industrial (e.g. Dr Simon T Barry - AstraZeneca & Dr Sheelagh - Cyclacel, UK) researchers. This research could lead to improved clinical outcomes in blood cancer patients, such as survival and quality of life.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Williams, M., Guzman, M. & Wheadon, H.
Project: Research Grant
Williams, M. & Wagner, E.
Project: Knowledge Exchange
Williams, M., Mulheran, P. & Wagner, E.
Dhx38 is required for the maintenance and differentiation of erythro-myeloid progenitors and hematopoietic stem cells by alternative splicingTu, J., Yu, S., Li, J., Ren, M., Zhang, Y., Luo, J., Sun, K., Lv, Y., Han, Y., Huang, Y., Ren, X., Jiang, T., Tang, Z., Williams, M. T. S., Lu, Q. & Liu, M., Sep 2022, In: Development (Cambridge, England). 149, 17, dev200450.
Research output: Contribution to journal › Article › peer-review
Targeting 3D chromosomal architecture at the RANK loci to suppress myeloma-driven osteoclastogenesisThümmler, K., Williams, M. T. S., Kitson, S., Sood, S., Akbar, M., Cole, J. J., Hunter, E., Soutard, R. & Goodyear, C. S., 31 Dec 2022, In: OncoImmunology. 11, 1, 10 p., 2104070.
Research output: Contribution to journal › Article › peer-reviewOpen AccessFile6 Downloads (Pure)
Farhan, F., Almarhoun, M., Wong, A., Findlay, A. S., Bartholomew, C., Williams, M. T. S., Hurd, T. W. & Shu, X., 7 Nov 2021, In: Cells. 10, 11, 16 p., 3066.
Research output: Contribution to journal › Article › peer-reviewOpen AccessFile1 Citation (Scopus)42 Downloads (Pure)
Macrophages in acute myeloid leukaemia: significant players in therapy resistance and patient outcomesMiari, K. E., Guzman, M. L., Wheadon, H. & Williams, M. T. S., 24 Jun 2021, In: Frontiers in Cell and Developmental Biology. 9, p. 1-14 14 p., 692800.
Research output: Contribution to journal › Review article › peer-reviewOpen AccessFile9 Citations (Scopus)59 Downloads (Pure)
Pujol-Navarro, N., Al Qaraghuli, M. M., Kubiak-Ossowska, K., Alsaadi, M. M., Horne, G. A., Soutar, R. L., Paspali, E., Ferro, V. A., Williams, M. T. S. & Mulheran, P. A., Oct 2021, In: Therapeutic Delivery. 12, 10, p. 705-722 18 p.
Research output: Contribution to journal › Review article › peer-reviewOpen AccessFile2 Citations (Scopus)16 Downloads (Pure)