Projects per year
Personal profile
Research interests
I am a newly appointed lecturer currently developing an independent research group. I have acquired extensive experience in the design, delivery and assessment of teaching and learning activities undertaken by biomedical science students both in China and Scotland.
I have over 7 years of expertise in researching blood cancers, including Acute Lymphoblastic Leukaemia and Mutliple Myeloma, and have identified new potentially targetable disease mechanisms. Currently, the leukemia field is shifting from a leukemic cell-centered research perspective to a view in which the environment within the bone marrow (BMME) is considered increasingly important in shielding leukemic cells from chemotherapy drugs (chemoresistance). Strategies thus far for modeling and targeting leukaemia – BMME cross-talk, however are currently inadequate. My independent research is focusing on using a unique 3D co-culture system for better modelling and targeting of BMME-mediated chemoresistance mechanisms in AML. This research has the potential to discover novel targetable mechanisms of disease in AML and other blood cancers. I am performing clinically relevant research studies, by collaborating with key academic (e.g. Dr Monica L Guzman - Cornell University, USA & Professor Mhairir Copland - University of Glasgow UK) and industrial (e.g. Dr Simon T Barry - AstraZeneca & Dr Sheelagh - Cyclacel, UK) researchers. This research could lead to improved clinical outcomes in blood cancer patients, such as survival and quality of life.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Investigating immune cell “macrophage” driven drug resistance in Acute Myeloid Leukaemia
Williams, M., Guzman, M. & Wheadon, H.
Project: Research Grant
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Generating a novel high-affinity multi-targeting therapeutic antibody for Multiple Myeloma
Williams, M. & Wagner, E.
Project: Knowledge Exchange
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Macrophage mediated chemoresistance in AML: from macrophage subset characterisation to the potential for therapeutic targeting.
Williams, M., Guzman, M. & Wheadon, H.
British Society for Haemotology
1/07/21 → 31/08/21
Project: Research Grant
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Investigating the use of Keap1-Nrf2 protein-protein interaction disruptors in Alzheimer's disease
Williams, M. & Kerr, F.
Scottish Dementia Research Consortium
1/08/20 → 31/03/22
Project: Research Grant
Research output
- 162 Citations
- 5 h-Index
- 15 Article
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Deletion of TSPO causes dysregulation of cholesterol metabolism in mouse retina
Farhan, F., Almarhoun, M., Wong, A., Findlay, A. S., Bartholomew, C., Williams, M. T. S., Hurd, T. W. & Shu, X., 7 Nov 2021, In: Cells. 10, 11, 16 p., 3066.Research output: Contribution to journal › Article › peer-review
Open AccessFile13 Downloads (Pure) -
Macrophages in acute myeloid leukaemia: significant players in therapy resistance and patient outcomes
Miari, K. E., Guzman, M. L., Wheadon, H. & Williams, M. T. S., 24 Jun 2021, In: Frontiers in Cell and Developmental Biology. 9, 14 p., 692800.Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Citations (Scopus)22 Downloads (Pure) -
Multiple myeloma: therapeutic delivery of antibodies and aptamers
Pujol-Navarro, N., Al Qaraghuli, M. M., Kubiak-Ossowska, K., Alsaadi, M. M., Horne, G. A., Soutar, R. L., Paspali, E., Ferro, V. A., Williams, M. T. S. & Mulheran, P. A., Oct 2021, In: Therapeutic Delivery. 12, 10, p. 705-722 18 p.Research output: Contribution to journal › Article › peer-review
1 Citation (Scopus) -
Bronchial epithelial cell lines and primary nasal epithelial cells from cystic fibrosis respond differently to cigarette smoke exposure
Williams, M. T. S., de Courcey, F., Comer, D., Elborn, J. S. & Ennis, M., Jul 2016, In: Journal of Cystic Fibrosis. 15, 4, p. 467-472 6 p.Research output: Contribution to journal › Article › peer-review
3 Citations (Scopus) -
The ability to cross the blood-cerebrospinal fluid barrier is a generic property of acute lymphoblastic leukemia blasts
Williams, M. T. S., Yousafzai, Y. M., Elder, A., Rehe, K., Bomken, S., Frishman-Levy, L., Tavor, S., Sinclair, P., Dormon, K., Masic, D., Perry, T., Weston, V. J., Kearns, P., Blair, H., Russell, L. J., Heidenreich, O., Irving, J. A. E., Izraeli, S., Vormoor, J., Graham, G. J. & 1 others, , 21 Apr 2016, In: Blood. 127, 16, p. 1998-2006 9 p.Research output: Contribution to journal › Article › peer-review
45 Citations (Scopus)