Photo of Mark Williams
  • 70 Cowcaddens Road, Glasgow Caledonian University

    G4 0BA Glasgow

    United Kingdom

20082016

Research output per year

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Personal profile

Research interests

I am a newly appointed lecturer currently developing an independent research group. I have acquired extensive experience in the design, delivery and assessment of teaching and learning activities undertaken by biomedical science students both in China and Scotland.

I have over 7 years of expertise in researching blood cancers, including Acute Lymphoblastic Leukaemia and Mutliple Myeloma, and have identified new potentially targetable disease mechanisms. Currently, the leukemia field is shifting from a leukemic cell-centered research perspective to a view in which the environment within the bone marrow (BMME) is considered increasingly important in shielding leukemic cells from chemotherapy drugs (chemoresistance). Strategies thus far for modeling and targeting leukaemia – BMME cross-talk, however are currently inadequate. My independent research is focusing on using a unique 3D co-culture system for better modelling and targeting of BMME-mediated chemoresistance mechanisms in AML. This research has the potential to discover novel targetable mechanisms of disease in AML and other blood cancers. I am performing clinically relevant research studies, by collaborating with key academic (e.g. Dr Monica L Guzman - Conrell University, USA & Professor Mhairir Copland - University of Glasgow UK) and industrial (e.g. Dr Simon T Barry - AstraZeneca & Dr Sheelagh - Cyclacel, UK) researchers. This research could lead to improved clinical outcomes in blood cancer patients, such as survival and quality of life.

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Research Output

Bronchial epithelial cell lines and primary nasal epithelial cells from cystic fibrosis respond differently to cigarette smoke exposure

Williams, M. T. S., de Courcey, F., Comer, D., Elborn, J. S. & Ennis, M., Jul 2016, In : Journal of Cystic Fibrosis. 15, 4, p. 467-472 6 p.

Research output: Contribution to journalArticle

  • The ability to cross the blood-cerebrospinal fluid barrier is a generic property of acute lymphoblastic leukemia blasts

    Williams, M. T. S., Yousafzai, Y. M., Elder, A., Rehe, K., Bomken, S., Frishman-Levy, L., Tavor, S., Sinclair, P., Dormon, K., Masic, D., Perry, T., Weston, V. J., Kearns, P., Blair, H., Russell, L. J., Heidenreich, O., Irving, J. A. E., Izraeli, S., Vormoor, J., Graham, G. J. & 1 others, Halsey, C., 21 Apr 2016, In : Blood. 127, 16, p. 1998-2006 9 p.

    Research output: Contribution to journalArticle

  • Targeting of Fc receptors reduces bone disease in a pre-clinical model of multiple myeloma

    Williams, M., Thuemmler, K., Kitson, S., Soutar, R. & Goodyear, C., 6 Dec 2015, In : Blood. 126, p. 3011 1 p.

    Research output: Contribution to journalArticle

  • Interleukin-15 enhances cellular proliferation and up-regulates CNS homing molecules in pre-B acute lymphoblastic leukemia

    Williams, M. T. S., Yousafzai, Y., Cox, C., Blair, A., Carmody, R., Sai, S., Chapman, K. E., McAndrew, R., Thomas, A., Spence, A., Gibson, B., Graham, G. J. & Halsey, C., 15 May 2014, In : Blood. 123, 20, p. 3116-3127 12 p.

    Research output: Contribution to journalArticle

  • An analysis of mechanisms of central nervous system infiltration in acute lymphoblastic leukaemia using primary cells xenografted into immunodeficient mice

    Yousafzai, Y., Williams, M., Rehe, K., Le Brocq, M., Bomken, S., Sinclair, P., Dormon, K., Masic, D., Archer, L., Watt, J., Perry, T., Weston, V., Kearns, P., Blair, H., Russel, L., Heidenreich, O., Irving, J., Vormoor, J., Gibson, B., Graham, G. & 1 others, Halsey, C., 5 Dec 2013, In : Blood. 122, 21, p. 3899 1 p.

    Research output: Contribution to journalArticle