Photo of Linda Scobie
  • 70 Cowcaddens Road, Glasgow Caledonian University

    G4 0BA Glasgow

    United Kingdom

19952020

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2020

Immunological response in cynomolgus macaques to porcine α-1,3 galactosyltransferase knockout viable skin xenotransplants: a pre-clinical study

Holzer, P. W., Chang, E., Wicks, J., Scobie, L., Crossan, C. & Monroy, R., 11 Aug 2020, In : Xenotransplantation. 12 p., e12632.

Research output: Contribution to journalArticle

2019

Third WHO Global Consultation on regulatory requirements for xenotransplantation clinical trials, Changsha, Hunan, China December 12-14, 2018: "The 2018 Changsha Communiqué" The 10-Year Anniversary of The International Consultation on Xenotransplantation

Hawthorne, W. J., Cowan, P. J., Bühler, L. H., Yi, S., Bottino, R., Pierson, R. N., Ahn, C., Azimzadeh, A., Cozzi, E., Gianello, P., Lakey, J. R. T., Luo, M., Miyagawa, S., Mohiuddin, M. M., Park, C-G., Schuurman, H-J., Scobie, L., Sykes, M., Tector, J., Tönjes, R. R. & 3 others, Wolf, E., Nuñez, J. R. & Wang, W., Apr 2019, In : Xenotransplantation. 26, 2, 25 p., e12513.

Research output: Contribution to journalArticle

Open Access
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26 Downloads (Pure)
2018

Assessment of porcine endogenous retrovirus transmission across an alginate barrier used for the encapsulation of porcine islets

Crossan, C., Mourad, N. I., Smith, K., Gianello, P. & Scobie, L., Dec 2018, In : Xenotransplantation. 25, 6, e12409.

Research output: Contribution to journalArticle

Open Access
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69 Downloads (Pure)

Examining the potential for porcine-derived islet cells to harbour viral pathogens

Crossan, C., O'Hara, Z., Mourad, N., Gianello, P. & Scobie, L., Apr 2018, In : Xenotransplantation. 25, 2, e12375.

Research output: Contribution to journalArticle

Open Access
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51 Downloads (Pure)

First report of the presence of hepatitis E virus in Scottish harvested shellfish purchased at retail level

O'Hara, Z., Crossan, C., Craft, J. & Scobie, L., 13 Feb 2018, In : Food and Environmental Virology. 10, p. 217-221 5 p.

Research output: Contribution to journalArticle

Open Access
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227 Downloads (Pure)

Hepatitis E virus (HEV) in Scotland: evidence of recent increase in viral circulation in humans

Thom, K., Gilhooly, P., McGowan, K., Malloy, K., Jarvis, L. M., Crossan, C., Scobie, L., Blatchford, O., Smith-Palmer, A., Donnelly, M. C., Davidson, J. S., Johannessen, I., Simpson, K. J., Dalton, H. R. & Petrik, J., 22 Mar 2018, In : Eurosurveillance. 23, 12, 10 p.

Research output: Contribution to journalArticle

Open Access
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156 Downloads (Pure)
2017

Characterization of porcine endogenous retrovirus expression in neonatal and adult pig pancreatic islets

Mourad, N. I., Crossan, C., Cruikshank, V., Scobie, L. & Gianello, P., Aug 2017, In : Xenotransplantation. 24, 4, e12311.

Research output: Contribution to journalArticle

Open Access
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83 Downloads (Pure)

Detection of viral hepatitis E in clinical liver biopsies

Prost, S., Crossan, C. L., Dalton, H. R., De Man, R. A., Kamar, N., Selves, J., Dhaliwal, C., Scobie, L. & Bellamy, C. O. C., Oct 2017, In : Histopathology. 71, 4, p. 580-590 11 p.

Research output: Contribution to journalArticle

Open Access
File
88 Downloads (Pure)

Hepatitis E: a concise review of virology, epidemiology, clinical presentation and therapy

Donnelly, M. C., Scobie, L., Crossan, C. L., Dalton, H., Hayes, P. C. & Simpson, K. J., Jul 2017, In : Alimentary Pharmacology and Therapeutics. 46, 2, p. 126-141 16 p.

Research output: Contribution to journalArticle

Open Access
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79 Downloads (Pure)

Posttransplant lymphoproliferative disorders in neuronal xenotransplanted macaques

Cavicchioli, L., Ferraresso, S., Westmoreland, S., Kaliyaperumal, S., Knight, H., Crossan, C., Scobie, L., Danesi, A., Vadori, M., Trez, D., Aron Badin, R., Hantraye, P. & Cozzi, E., Mar 2017, In : Veterinary Pathology. 54, 2

Research output: Contribution to journalArticle

Open Access
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81 Downloads (Pure)
2016

Selective CD28 antagonist blunts memory immune responses and promotes long-term control of skin inflammation in nonhuman primates

Poirier, N., Chevalier, M., Mary, C., Hervouet, J., Minault, D., Baker, P., Ville, S., Le Bas-Bernardet, S., Dilek, N., Belarif, L., Cassagnau, E., Scobie, L., Blancho, G. & Vanhove, B., 1 Jan 2016, In : Journal of Immunology. 196, 1, p. 274-283 10 p.

Research output: Contribution to journalArticle

2015

Bortezomib, C1-inhibitor and plasma exchange do not prolong the survival of multi-transgenic GalT-KO pig kidney xenografts in baboons

Le Bas-Bernardet, S., Tillou, X., Branchereau, J., Dilek, N., Poirier, N., Chatelais, M., Charreau, B., Minault, D., Hervouet, J., Renaudin, K., Crossan, C., Scobie, L., Takeuchi, Y., Diswall, M., Breimer, M. E., Klar, N., Daha, M. R., Simioni, P., Robson, S. C., Nottle, M. B. & 14 others, Salvaris, E. J., Cowan, P. J., d'Apice, A. J. F., Sachs, D. H., Yamada, K., Lagutina, I., Duchi, R., Perota, A., Lazzari, G., Galli, C., Cozzi, E., Soulillou, J. P., Vanhove, B. & Blancho, G., Feb 2015, In : American Journal of Transplantation. 15, 2, p. 358–370 13 p.

Research output: Contribution to journalArticle

Correction: selective blockade of CD28-mediated T cell costimulation protects rhesus monkeys against acute fatal experimental autoimmune encephalomyelitis

Haanstra, K. G., Dijkman, K., Bashir, N., Bauer, J., Mary, C., Poirier, N., Baker, P., Crossan, C., Scobie, L., 't Hart, B. A. & Vanhove, B., 15 Jul 2015, In : Journal of Immunology. 195, 2

Research output: Contribution to journalArticle

Expression of recipient cytomegalovirus in immunosuppressed and xenotransplanted Macaca fascicularis may be related to more severe gastrointestinal lesions

Cavicchioli, L., Zanetti, R., Ferraresso, S., Crossan, C., Barry, P. A., Boldrin, M., Vadori, M., Ferro, S., Calabrese, F., Scobie, L., Cozzi, E. & Zappulli, V., Mar 2015, In : Xenotransplantation. 22, 2, p. 135–143 9 p.

Research output: Contribution to journalArticle

Hepatitis E virus in patients with decompensated chronic liver disease: a prospective UK/French study

Blasco-Perrin, H., Madden, R. G., Stanley, A., Crossan, C., Hunter, J. G., Vine, L., Lane, K., Devooght-Johnson, N., Mclaughlin, C., Petrik, J., Stableforth, B., Hussaini, H., Phillips, M., Mansuy, J. M., Forrest, E., Izopet, J., Blatchford, O., Scobie, L., Peron, J. M. & Dalton, H. R., Sep 2015, In : Alimentary Pharmacology and Therapeutics. 42, 5, p. 574-581 8 p.

Research output: Contribution to journalArticle

Prevalence of hepatitis E virus in slaughter-age pigs in Scotland

Crossan, C., Grierson, S., Thomson, J., Ward, A., Nunez-Garcia, J., Banks, M. & Scobie, L., Jul 2015, In : Epidemiology and Infection. 143, 10, p. 2237-2240 4 p.

Research output: Contribution to journalArticle

Selective blockade of CD28-mediated T cell costimulation protects rhesus monkeys against acute fatal experimental autoimmune encephalomyelitis

Haanstra, K. G., Dijkman, K., Bashir, N., Bauer, J., Mary, C., Poirier, N., Baker, P., Scobie, L., ’t Hart, B. A. & Vanhove, B., Feb 2015, In : Journal of Immunology. 194, 4, p. 1454-1466 13 p.

Research output: Contribution to journalArticle

Unusual serological response to hepatitis E virus in plasma donors consistent with re-infection

Baylis, S. A., Crossan, C., Corman, V. M., Blumel, J., Scobie, L. & Dalton, H. R., Nov 2015, In : Vox Sanguinis. 109, 4, p. 406-409 4 p.

Research output: Contribution to journalArticle

2014

Antibiotic susceptibility and resistance of Staphylococcus aureus isolated from fresh porcine skin xenografts: risk to recipients with thermal injury

Busby, S-A., Robb, A., Lang, S., Takeuchi, Y., Vesely, P. & Scobie, L., Mar 2014, In : Burns. 40, 2, p. 288-294 7 p.

Research output: Contribution to journalArticle

Hepatitis E virus in patients with acute severe liver injury

Crossan, C., Simpson, K. J., Craig, D. G., Bellamy, C., Davidson, J., Dalton, H. & Scobie, L., Jun 2014, In : world journal of hepatology. 6, 6, p. 426-434 9 p.

Research output: Contribution to journalArticle

The International Xenotransplantation Association consensus statement on conditions for undertaking clinical trials of xenocorneal transplantation

Kim, M. K., Choi, H. J., Kwon, I., Pierson, R. N., Cooper, D. K. C., Soulillou, J-P., O'Connell, P. J., Vabres, B., Maeda, N., Hara, H., Scobie, L., Gianello, P., Takeuchi, Y., Yamada, K., Hwang, E-S., Kim, S. J. & Park, C-G., Oct 2014, In : Xenotransplantation. 21, 5, p. 420-430 11 p.

Research output: Contribution to journalArticle

2013

Hepatitis E: source and route of infection, clinical manifestations and new developments

Scobie, L. & Dalton, H., Jan 2013, In : Journal of Viral Hepatitis. 20, 1, p. 1-11 11 p.

Research output: Contribution to journalArticle

Hepatitis E seroprevalence in recipients of renal transplants or haemodialysis in southwest England: a case-control study

Harrison, A., Scobie, L., Crossan, C., Parry, R., Johnston, P., Stratton, J., Dickinson, S., Ellis, V., Hunter, J. G., Prescott, O. R., Madden, R., Lin, N. X., Henley, W. E., Bendall, R. P. & Dalton, H., Feb 2013, In : Journal of Medical Virology. 85, 2, p. 266-271 6 p.

Research output: Contribution to journalArticle

Hepatitis E virus in Scottish blood donors

Cleland, A., Smith, L., Crossan, C., Blatchford, O., Dalton, H., Scobie, L. & Petrik, J., 2013, In : Vox Sanguinis.

Research output: Contribution to journalArticle

Long-term IgG response to porcine Neu5Gc antigens without transmission of PERV in burn patients treated with porcine skin xenografts

Scobie, L., Padler-Karavani, V., Le Bas-Bernardet, S., Crossan, C., Blaha, J., Matouskova, M., Hector, R. D., Cozzi, E., Vanhove, B., Charreau, B., Blancho, G., Bourdais, L., Tallacchini, M., Ribes, J. M., Yu, H., Chen, X., Kracikova, J., Broz, L., Hejnar, J., Vesely, P. & 3 others, Takeuchi, Y., Varki, A. & Soulillou, J-P., Sep 2013, In : Journal of Immunology. 191, 6, p. 2907-2915 9 p.

Research output: Contribution to journalArticle

Suggestions for the diagnosis and elimination of hepatitis E virus in pigs used for xenotransplantation

Busby, S., Crossan, C., Godwin, J., Petersen, B., Galli, C., Cozzi, E., Takeuchi, Y. & Scobie, L., Jun 2013, In : Xenotransplantation. 20, 3, p. 188–192 5 p.

Research output: Contribution to journalArticle

The role of DNA methylation in expression and transmission of porcine endogenous retrovirus

Scobie, L., Nov 2013, In : Journal of Virology. 87, 22, p. 12110-12120 11 p.

Research output: Contribution to journalArticle

2012

Analyses of pig genomes provide insight into porcine demography and evolution

Scobie, L., Nov 2012, In : Nature. 491, 7424, p. 393–398 7 p.

Research output: Contribution to journalArticle

Xenotransplantation-associated infectious risk: a WHO consultation

Jay A., F., Scobie, L. & Takeuchi, Y., Apr 2012, In : Xenotransplantation. 19, 2, p. 72-81 10 p.

Research output: Contribution to journalArticle

2011

Detection of porcine endogenous retrovirus (PERV) viremia in diseased versus healthy US pigs by qualitative and quantitative Real-Time RT-PCR

Pal, N., Baker, R., Schalk, S., Scobie, L., Tucker, A. W. & Opriessnig, T., 1 Mar 2011, In : Transboundary and Emerging Diseases.

Research output: Contribution to journalArticle

First xenotransplantations of galactosyl-transferase knock-out, CD55, CD59, CD39 AND, fucosyl-transferase transgenic pig kidneys into baboons

Le Bas-Bernardet, S., Tillou, X., Poirier, N., Dilek, N., Chatelais, M., Devallière, J., Charreau, B., Minault, D., Crossan, C. & Scobie, L., 1 Jan 2011, In : Transplantation Proceedings.

Research output: Contribution to journalArticle

Microbial safety in xenotransplantation

Nicolas J., M., Yasuhiro, T., Giada, M. & Scobie, L., Apr 2011, In : Current Opinion in Organ Transplantation. 16, 2, p. 201-206 6 p.

Research output: Contribution to journalArticle

2010

Porcine pathogens and xenotransplantation: PERV and beyond!

Scobie, L., 1 Jan 2010, In : Xenotransplantation. 17, p. 94-120 27 p.

Research output: Contribution to journalArticle

Uptake of synthetic Low Density Lipoprotein by leukemic stem cells: a potential stem cell targeted drug delivery strategy

Zhou, P., Hatziieremia, S., Elliott, M. A., Scobie, L., Crossan, C., Michie, A. M., Holyoake, T. L., Halbert, G. W. & Jørgensen, H. G., 1 Dec 2010, In : Journal of Controlled Release. 148, 3, p. 380-387 8 p.

Research output: Contribution to journalArticle

2009

A novel model of SCID-X1 reconstitution reveals predisposition to retrovirus-induced lymphoma but no evidence of ¿C gene oncogenicity

Scobie, L., Hector, R., Grant, L., Bell, M., Neilsen, A. A., Meikle, S., Philbey, A. & Thrasher, A. J., 1 Mar 2009, In : Molecular Therapy. 17, 6, p. 1031-1038 8 p.

Research output: Contribution to journalArticle

Assessment of the potential risk of infection associated with Clostridium difficile from porcine xenografts

Bakri, M. M., Sutherland, A. D., Brown, D. J., Vesely, P., Crossan, C. & Scobie, L., 1 Dec 2009, In : Xenotransplantation. 16, 6, p. 472-476 5 p.

Research output: Contribution to journalArticle

Porcine endogenous retrovirus and other viruses in xenotransplantation

Scobie, L. & Takeuchi, Y., 1 Apr 2009, In : Current Opinion in Organ Transplantation. 14, 2, p. 175-179 5 p.

Research output: Contribution to journalArticle

2008

Porcine endogenous retrovirus (PERV) and its transmission characteristics: a study of the New Zealand designated pathogen-free herd

Garkavenko, O., Wynyard, S., Nathu, D., Simond, D., Muzina, M., Muzina, Z., Scobie, L. & Hector, R., 1 Jan 2008, In : Cell Transplantation. 17, 12, p. 1381-1388 8 p.

Research output: Contribution to journalArticle

Porcine endogenous retrovirus transmission characteristics from a designated pathogen-free herd

Garkavenko, O., Wynyard, S., Nathu, D., Muzina, M., Muzina, Z., Scobie, L., Hector, R. & Croxson, M. C., 1 Mar 2008, In : Transplantation Proceedings. 40, 2, p. 590-593 4 p.

Research output: Contribution to journalArticle

Strategies to enhance the safety profile of xenotransplantation: minimizing the risk of viral zoonoses

Mattiuzzo, G., Scobie, L. & Takeuchi, Y., 1 Apr 2008, In : Current Opinion in Organ Transplantation. 13, 2, p. 184-188 5 p.

Research output: Contribution to journalArticle

2007

Insertional mutagenesis reveals progression genes and checkpoints in MYC/Runx2 lymphomas

Stewart, M., Mackay, N., Hanlon, L., Blyth, K., Scobie, L., Cameron, E. & Neil, J. C., 1 Jun 2007, In : Cancer Research.

Research output: Contribution to journalArticle

Pre-screening of miniature swine may reduce the risk of transmitting human tropic recombinant porcine endogenous retroviruses

Hector, R. D., Meikle, S., Grant, L., Wilkinson, R. A., Fishman, J. A. & Scobie, L., 2 May 2007, In : Xenotransplantation. 14, 3, p. 222-226 6 p.

Research output: Contribution to journalArticle

2006

Retroviraemia and low health status in pigs

Tucker, A. W. & Scobie, L., 9 Sep 2006, In : Vet Record. 159, 11, p. 367-368 2 p.

Research output: Contribution to journalArticle

Retroviremia in commercial pigs and its preliminary association with poor health

Tucker, A. W. D., Mellencamp, M. M., Donadeu, M. & Scobie, L., Oct 2006, In : Journal of Clinical Microbiology. 44, 10, p. 3846-7 2 p.

Research output: Contribution to journalArticle

2004

Absence of replication competent human-tropic porcine endogenous retroviruses in the germline DNA of inbred miniature swine

Scobie, L., Taylor, S., Wood, J. C., Suling, K. M., Quinn, G., Meikle, S., Patience, C. & Schuurman, H-J., 1 Mar 2004, In : Journal of Virology.

Research output: Contribution to journalArticle

Characterization of germline porcine endogenous retroviruses from large white pig.

Scobie, L., Taylor, S., Logan, N. A., Meikle, S., Onions, D., Patience, C. & Quinn, G., Aug 2004, In : Journal of General Virology. 85, 8, p. 2421-2428 8 p.

Research output: Contribution to journalArticle

Identification of exogenous forms of human-tropic porcine endogenous retrovirus in miniature swine

Wood, J. C., Quinn, G., Suling, K. M., Oldmixon, B. A., Van Tine, B. A., Cina, R., Arn, S., Huang, C. A. & Scobie, L., 1 Mar 2004, In : Journal of Virology.

Research output: Contribution to journalArticle

2002

Porcine endogenous retrovirus: advances, issues and solutions

Patience, C., Scobie, L. & Quinn, G., 4 Nov 2002, In : Xenotransplantation. 9, 6, p. 373-375 3 p.

Research output: Contribution to journalArticle