Photo of Linda Scobie

Linda Scobie

Professor

  • 70 Cowcaddens Road, Glasgow Caledonian University

    G4 0BA Glasgow

    United Kingdom

19952019
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Research Output 1995 2019

Absence of replication competent human-tropic porcine endogenous retroviruses in the germline DNA of inbred miniature swine

Scobie, L., Taylor, S., Wood, J. C., Suling, K. M., Quinn, G., Meikle, S., Patience, C. & Schuurman, H-J., 1 Mar 2004, In : Journal of Virology.

Research output: Contribution to journalArticle

Retroviridae
Endogenous Retroviruses
Miniature Swine
miniature swine
germ cells

Analyses of pig genomes provide insight into porcine demography and evolution

Scobie, L., Nov 2012, In : Nature. 491, 7424, p. 393–398 7 p.

Research output: Contribution to journalArticle

demography
swine
genome
Duroc
Sus scrofa

A novel model of SCID-X1 reconstitution reveals predisposition to retrovirus-induced lymphoma but no evidence of ¿C gene oncogenicity

Scobie, L., Hector, R., Grant, L., Bell, M., Neilsen, A. A., Meikle, S., Philbey, A. & Thrasher, A. J., 1 Mar 2009, In : Molecular Therapy. 17, 6, p. 1031-1038 8 p.

Research output: Contribution to journalArticle

Retroviridae
Lymphoma
X-Linked Combined Immunodeficiency Diseases
Locus Control Region
Cytokine Receptors

Antibiotic susceptibility and resistance of Staphylococcus aureus isolated from fresh porcine skin xenografts: risk to recipients with thermal injury

Busby, S-A., Robb, A., Lang, S., Takeuchi, Y., Vesely, P. & Scobie, L., Mar 2014, In : Burns. 40, 2, p. 288-294 7 p.

Research output: Contribution to journalArticle

Zoonoses
Microbial Drug Resistance
Heterografts
Staphylococcus aureus
Swine

Are there better assays to evaluate the risk of transmission of porcine endogenous retroviruses (PERVs) to human cells?

Denner, J. & Scobie, L., 29 Aug 2019, In : Xenotransplantation. 26, 4, 3 p., e12510.

Research output: Contribution to journalLetter

18 Downloads (Pure)

Assessment of porcine endogenous retrovirus transmission across an alginate barrier used for the encapsulation of porcine islets

Crossan, C., Mourad, N. I., Smith, K., Gianello, P. & Scobie, L., Dec 2018, In : Xenotransplantation. 25, 6, e12409.

Research output: Contribution to journalArticle

Open Access
File
Endogenous Retroviruses
Swine
Testis
Cultured Cells
alginic acid

Assessment of the potential risk of infection associated with Clostridium difficile from porcine xenografts

Bakri, M. M., Sutherland, A. D., Brown, D. J., Vesely, P., Crossan, C. & Scobie, L., 1 Dec 2009, In : Xenotransplantation. 16, 6, p. 472-476 5 p.

Research output: Contribution to journalArticle

Clostridium difficile
Heterografts
Heterologous Transplantation
Swine
Zoonoses

Assignment of the bovine p53 gene (TP53) to Chromosome 19q15 by fluorescence in situ hybridization

Coggins, L. W., Scobie, L., Jackson, M. E. & Campo, M. S., Sep 1995, In : Mammalian Genome. 6, 9, p. 687-8 2 p.

Research output: Contribution to journalArticle

Bortezomib, C1-inhibitor and plasma exchange do not prolong the survival of multi-transgenic GalT-KO pig kidney xenografts in baboons

Le Bas-Bernardet, S., Tillou, X., Branchereau, J., Dilek, N., Poirier, N., Chatelais, M., Charreau, B., Minault, D., Hervouet, J., Renaudin, K., Crossan, C., Scobie, L., Takeuchi, Y., Diswall, M., Breimer, M. E., Klar, N., Daha, M. R., Simioni, P., Robson, S. C., Nottle, M. B. & 14 others, Salvaris, E. J., Cowan, P. J., d'Apice, A. J. F., Sachs, D. H., Yamada, K., Lagutina, I., Duchi, R., Perota, A., Lazzari, G., Galli, C., Cozzi, E., Soulillou, J. P., Vanhove, B. & Blancho, G., Feb 2015, In : American Journal of Transplantation. 15, 2, p. 358–370 13 p.

Research output: Contribution to journalArticle

Plasma Exchange
Papio
Transferases
Heterografts
Swine
40 Downloads (Pure)

Cellular xenotransplantation of animal cells into people: benefits and risk

Scobie, L., Galli, C., Gianello, P., Cozzi, E. & Schuurman, H-J., 30 Apr 2018, Scientific and Technical Review. OIE, Vol. 37. p. 113-122

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Open Access
File
Heterologous Transplantation
Swine
Tissue and Organ Procurement
Safety
Animal Welfare

Characterization of germline porcine endogenous retroviruses from large white pig.

Scobie, L., Taylor, S., Logan, N. A., Meikle, S., Onions, D., Patience, C. & Quinn, G., Aug 2004, In : Journal of General Virology. 85, 8, p. 2421-2428 8 p.

Research output: Contribution to journalArticle

Endogenous Retroviruses
Swine
Proviruses
Miniature Swine
Heterologous Transplantation
51 Downloads (Pure)

Characterization of porcine endogenous retrovirus expression in neonatal and adult pig pancreatic islets

Mourad, N. I., Crossan, C., Cruikshank, V., Scobie, L. & Gianello, P., Aug 2017, In : Xenotransplantation. 24, 4, e12311.

Research output: Contribution to journalArticle

Open Access
File
Endogenous Retroviruses
Islets of Langerhans
Swine
Pancreas
Heterologous Transplantation

Correction: selective blockade of CD28-mediated T cell costimulation protects rhesus monkeys against acute fatal experimental autoimmune encephalomyelitis

Haanstra, K. G., Dijkman, K., Bashir, N., Bauer, J., Mary, C., Poirier, N., Baker, P., Crossan, C., Scobie, L., 't Hart, B. A. & Vanhove, B., 15 Jul 2015, In : Journal of Immunology. 195, 2

Research output: Contribution to journalArticle

Detection of porcine endogenous retrovirus (PERV) viremia in diseased versus healthy US pigs by qualitative and quantitative Real-Time RT-PCR

Pal, N., Baker, R., Schalk, S., Scobie, L., Tucker, A. W. & Opriessnig, T., 1 Mar 2011, In : Transboundary and Emerging Diseases.

Research output: Contribution to journalArticle

Retroviridae
Endogenous Retroviruses
Viremia
viremia
Real-Time Polymerase Chain Reaction
42 Downloads (Pure)

Detection of viral hepatitis E in clinical liver biopsies

Prost, S., Crossan, C. L., Dalton, H. R., De Man, R. A., Kamar, N., Selves, J., Dhaliwal, C., Scobie, L. & Bellamy, C. O. C., Oct 2017, In : Histopathology. 71, 4, p. 580-590 11 p.

Research output: Contribution to journalArticle

Open Access
File
Hepatitis E
Hepatitis E virus
Biopsy
Polymerase Chain Reaction
Liver
16 Downloads (Pure)

Examining the potential for porcine-derived islet cells to harbour viral pathogens

Crossan, C., O'Hara, Z., Mourad, N., Gianello, P. & Scobie, L., Apr 2018, In : Xenotransplantation. 25, 2, e12375.

Research output: Contribution to journalArticle

Open Access
File
Islets of Langerhans
Swine
Viruses
Newborn Animals
Hygiene

Expression of recipient cytomegalovirus in immunosuppressed and xenotransplanted Macaca fascicularis may be related to more severe gastrointestinal lesions

Cavicchioli, L., Zanetti, R., Ferraresso, S., Crossan, C., Barry, P. A., Boldrin, M., Vadori, M., Ferro, S., Calabrese, F., Scobie, L., Cozzi, E. & Zappulli, V., Mar 2015, In : Xenotransplantation. 22, 2, p. 135–143 9 p.

Research output: Contribution to journalArticle

Heterologous Transplantation
Macaca fascicularis
Zoonoses
Cytomegalovirus
Primates
153 Downloads (Pure)
Open Access
File
Hepatitis E virus
Shellfish
shellfish
Scotland
supermarkets
Heterologous Transplantation
Swine
Clinical Trials
Heterografts
Immunosuppressive Agents
Heterologous Transplantation
Type 1 Diabetes Mellitus
Swine
Clinical Trials
Endogenous Retroviruses

First xenotransplantations of galactosyl-transferase knock-out, CD55, CD59, CD39 AND, fucosyl-transferase transgenic pig kidneys into baboons

Le Bas-Bernardet, S., Tillou, X., Poirier, N., Dilek, N., Chatelais, M., Devallière, J., Charreau, B., Minault, D., Crossan, C. & Scobie, L., 1 Jan 2011, In : Transplantation Proceedings.

Research output: Contribution to journalArticle

Heterologous Transplantation
Papio
Transferases
Swine
Kidney

Gene therapy: X-SCID transgene leukaemogenicity

Scobie, L., Sep 2006, In : Nature. 443, p. E5-E6 2 p.

Research output: Contribution to journalComment/debate

X-Linked Combined Immunodeficiency Diseases
Transgenes
Genetic Therapy
Severe Combined Immunodeficiency
Interleukin-2 Receptors
23 Downloads (Pure)

Hepatitis E: a concise review of virology, epidemiology, clinical presentation and therapy

Donnelly, M. C., Scobie, L., Crossan, C. L., Dalton, H., Hayes, P. C. & Simpson, K. J., Jul 2017, In : Alimentary Pharmacology and Therapeutics. 46, 2, p. 126-141 16 p.

Research output: Contribution to journalArticle

Open Access
File
Hepatitis E
Virology
Epidemiology
Infection
Therapeutics

Hepatitis E: source and route of infection, clinical manifestations and new developments

Scobie, L. & Dalton, H., Jan 2013, In : Journal of Viral Hepatitis. 20, 1, p. 1-11 11 p.

Research output: Contribution to journalArticle

Hepatitis E
Infection
Zoonoses
Developed Countries
Hepatitis

Hepatitis E seroprevalence in recipients of renal transplants or haemodialysis in southwest England: a case-control study

Harrison, A., Scobie, L., Crossan, C., Parry, R., Johnston, P., Stratton, J., Dickinson, S., Ellis, V., Hunter, J. G., Prescott, O. R., Madden, R., Lin, N. X., Henley, W. E., Bendall, R. P. & Dalton, H., Feb 2013, In : Journal of Medical Virology. 85, 2, p. 266-271 6 p.

Research output: Contribution to journalArticle

Hepatitis E
Seroepidemiologic Studies
England
Renal Dialysis
Case-Control Studies

Hepatitis E virus: a potential risk for xenotransplantation?

Crossan, C. L., Busby, S., Wang, H., Takeuchi, Y., Banks, M. & Scobie, L., 30 Sep 2009, Xenotransplantation. John Wiley & Sons , p. 440 1 p. (Xenotransplantation; vol. 16, no. 5).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

101 Downloads (Pure)

Hepatitis E virus (HEV) in Scotland: evidence of recent increase in viral circulation in humans

Thom, K., Gilhooly, P., McGowan, K., Malloy, K., Jarvis, L. M., Crossan, C., Scobie, L., Blatchford, O., Smith-Palmer, A., Donnelly, M. C., Davidson, J. S., Johannessen, I., Simpson, K. J., Dalton, H. R. & Petrik, J., 22 Mar 2018, In : Eurosurveillance. 23, 12

Research output: Contribution to journalArticle

Open Access
File
Hepatitis E virus
Scotland
Seroepidemiologic Studies
Hepatitis E
Blood Donors

Hepatitis E virus and porcine-derived heparin

Crossan, C., Scobie, L., Godwin, J., Hunter, J. G., Hawkes, T. & Dalton, H., Apr 2013, In : Emerging Infectious Diseases. 19, 4, p. 686-688 3 p.

Research output: Contribution to journalLetter

Hepatitis E
Hepatitis E virus
Heparin
Swine
Meat Products

Hepatitis E virus and transfusion transmitted infection in Scotland

Scobie, L., Crossan, C., Davidson, J., Jarvis, L. & Simpson, K., Sep 2015, Journal of Clinical Virology: Abstracts of the 18th Annual Meeting of European Society for Clinical Virology, 9th–12th September 2015, Edinburgh. Elsevier B.V., Vol. 70. p. S124 1 p. (Journal of Clinical Virology; vol. 70, no. Supplement 1).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Hepatitis E virus
Scotland
Infection
Transplants
Seroepidemiologic Studies

Hepatitis E virus genotype 3 in shellfish, United Kingdom

Crossan, C., Baker, P., Craft, J., Yasu, T., Dalton, H. & Scobie, L., Dec 2012, In : Emerging Infectious Diseases. 18, 12, p. 2085-2087 2 p.

Research output: Contribution to journalLetter

Hepatitis E virus
Shellfish
Manure
Bivalvia
Genotype

Hepatitis E virus in patients with acute severe liver injury

Crossan, C., Simpson, K. J., Craig, D. G., Bellamy, C., Davidson, J., Dalton, H. & Scobie, L., Jun 2014, In : world journal of hepatology. 6, 6, p. 426-434 9 p.

Research output: Contribution to journalArticle

Hepatitis E virus
Hepatitis E
Liver
Wounds and Injuries
Immunoglobulin G

Hepatitis E virus in patients with decompensated chronic liver disease: a prospective UK/French study

Blasco-Perrin, H., Madden, R. G., Stanley, A., Crossan, C., Hunter, J. G., Vine, L., Lane, K., Devooght-Johnson, N., Mclaughlin, C., Petrik, J., Stableforth, B., Hussaini, H., Phillips, M., Mansuy, J. M., Forrest, E., Izopet, J., Blatchford, O., Scobie, L., Peron, J. M. & Dalton, H. R., Sep 2015, In : Alimentary Pharmacology and Therapeutics. 42, 5, p. 574-581 8 p.

Research output: Contribution to journalArticle

Hepatitis E
Hepatitis E virus
Liver Diseases
Chronic Disease
Genotype

Hepatitis E virus in Scottish blood donors

Cleland, A., Smith, L., Crossan, C., Blatchford, O., Dalton, H., Scobie, L. & Petrik, J., 2013, In : Vox Sanguinis.

Research output: Contribution to journalArticle

Hepatitis E virus
Blood Donors
Seroepidemiologic Studies
Blood Transfusion
RNA

Identification of exogenous forms of human-tropic porcine endogenous retrovirus in miniature swine

Wood, J. C., Quinn, G., Suling, K. M., Oldmixon, B. A., Van Tine, B. A., Cina, R., Arn, S., Huang, C. A. & Scobie, L., 1 Mar 2004, In : Journal of Virology.

Research output: Contribution to journalArticle

Retroviridae
Endogenous Retroviruses
Miniature Swine
miniature swine
tropics

Insertional mutagenesis reveals progression genes and checkpoints in MYC/Runx2 lymphomas

Stewart, M., Mackay, N., Hanlon, L., Blyth, K., Scobie, L., Cameron, E. & Neil, J. C., 1 Jun 2007, In : Cancer Research.

Research output: Contribution to journalArticle

Insertional Mutagenesis
Lymphoma
Genes
Neoplasms
Cyclin D
13 Downloads (Pure)

Is it currently possible to evaluate the risk posed by PERVs for clinical xenotransplantation?

Denner, J., Scobie, L. & Schuurman, H-J., 13 May 2018, In : Xenotransplantation. p. e12403

Research output: Contribution to journalComment/debate

Open Access
File
Heterologous Transplantation

Is the increase in hepatitis E in Scotland true or a reflection of testing patterns?

Crossan, C. L., Nair, S., Gunson, R., Burns, J. P., Smith-Palmer, A., Johannessen, I., Ramalingam, S. & Scobie, L., Sep 2015, Journal of Clinical Virology: Abstracts of the 18th Annual Meeting of European Society for Clinical Virology, 9th–12th September 2015, Edinburgh. Elsevier B.V., Vol. 70. p. S96-97 2 p. (Journal of Clinical Virology; vol. 70, no. Supplement 1).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Hepatitis E
Scotland
Immunoglobulin G
Immunoglobulin M
RNA

Long-term IgG response to porcine Neu5Gc antigens without transmission of PERV in burn patients treated with porcine skin xenografts

Scobie, L., Padler-Karavani, V., Le Bas-Bernardet, S., Crossan, C., Blaha, J., Matouskova, M., Hector, R. D., Cozzi, E., Vanhove, B., Charreau, B., Blancho, G., Bourdais, L., Tallacchini, M., Ribes, J. M., Yu, H., Chen, X., Kracikova, J., Broz, L., Hejnar, J., Vesely, P. & 3 others, Takeuchi, Y., Varki, A. & Soulillou, J-P., Sep 2013, In : Journal of Immunology. 191, 6, p. 2907-2915 9 p.

Research output: Contribution to journalArticle

Endogenous Retroviruses
Heterografts
Swine
Immunoglobulin G
Antigens

Mapping full length porcine endogenous retroviruses in a Large White pig

Herring, C., Quinn, G., Bower, R., Parsons, N., Logan, N. A., Brawley, A., Elsome, K., Whittam, A. & Scobie, L., 1 Dec 2001, In : Journal of Virology.

Research output: Contribution to journalArticle

Retroviridae
Endogenous Retroviruses
Large White
proviruses
Proviruses

Microbial safety in xenotransplantation

Nicolas J., M., Yasuhiro, T., Giada, M. & Scobie, L., Apr 2011, In : Current Opinion in Organ Transplantation. 16, 2, p. 201-206 6 p.

Research output: Contribution to journalArticle

Heterologous Transplantation
Swine
Safety
Viruses
Endogenous Retroviruses

PERVading strategies and infectious risk for clinical xenotransplantation

McGregor, C. G. A., Takeuchi, Y., Scobie, L. & Byrne, G., 18 Aug 2018, In : Xenotransplantation. 25, 4, p. e12402 3 p.

Research output: Contribution to journalComment/debate

Heterologous Transplantation

Porcine endogenous retrovirus: advances, issues and solutions

Patience, C., Scobie, L. & Quinn, G., 4 Nov 2002, In : Xenotransplantation. 9, 6, p. 373-375 3 p.

Research output: Contribution to journalArticle

Endogenous Retroviruses
Swine

Porcine endogenous retrovirus (PERV) and its transmission characteristics: a study of the New Zealand designated pathogen-free herd

Garkavenko, O., Wynyard, S., Nathu, D., Simond, D., Muzina, M., Muzina, Z., Scobie, L. & Hector, R., 1 Jan 2008, In : Cell Transplantation. 17, 12, p. 1381-1388 8 p.

Research output: Contribution to journalArticle

Endogenous Retroviruses
Pathogens
New Zealand
Swine
Heterologous Transplantation

Porcine endogenous retrovirus and other viruses in xenotransplantation

Scobie, L. & Takeuchi, Y., 1 Apr 2009, In : Current Opinion in Organ Transplantation. 14, 2, p. 175-179 5 p.

Research output: Contribution to journalArticle

Endogenous Retroviruses
Heterologous Transplantation
Zoonoses
Swine
Viruses

Porcine endogenous retroviruses in xenotransplantation

Scobie, L. & Garkavenko, O., 1 Jan 2011, The Minipig in Biomedical Research. CRC Press

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

regulatory authority
pharmacology
pharmaceutical industry
animal
welfare

Porcine endogenous retrovirus transmission characteristics from a designated pathogen-free herd

Garkavenko, O., Wynyard, S., Nathu, D., Muzina, M., Muzina, Z., Scobie, L., Hector, R. & Croxson, M. C., 1 Mar 2008, In : Transplantation Proceedings. 40, 2, p. 590-593 4 p.

Research output: Contribution to journalArticle

Endogenous Retroviruses
Swine
Heterologous Transplantation
New Zealand
Miniature Swine

Porcine pathogens and xenotransplantation: PERV and beyond!

Scobie, L., 1 Jan 2010, In : Xenotransplantation. 17, p. 94-120 27 p.

Research output: Contribution to journalArticle

Endogenous Retroviruses
Heterologous Transplantation
Swine
Viruses
Zoonoses
35 Downloads (Pure)

Posttransplant lymphoproliferative disorders in neuronal xenotransplanted macaques

Cavicchioli, L., Ferraresso, S., Westmoreland, S., Kaliyaperumal, S., Knight, H., Crossan, C., Scobie, L., Danesi, A., Vadori, M., Trez, D., Aron Badin, R., Hantraye, P. & Cozzi, E., Mar 2017, In : Veterinary Pathology. 54, 2

Research output: Contribution to journalArticle

Open Access
File
lymphatic diseases
Lymphoproliferative Disorders
Macaca
Lymphocryptovirus
Primates

Potential zoonotic infection of porcine endogenous retrovirus in xenotransplantation

Mattiuzzo, G., Takeuchi, Y. & Scobie, L., 2012, Xenotransplantation : Methods in Molecular Biology. Costa, C. & Máñez, R. (eds.). Humana Press, p. 263-279 16 p. (Methods in Molecular Biology ).

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Endogenous Retroviruses
Heterologous Transplantation
Zoonoses
Swine
Retroviridae Infections

Pre-screening of miniature swine may reduce the risk of transmitting human tropic recombinant porcine endogenous retroviruses

Hector, R. D., Meikle, S., Grant, L., Wilkinson, R. A., Fishman, J. A. & Scobie, L., 2 May 2007, In : Xenotransplantation. 14, 3, p. 222-226 6 p.

Research output: Contribution to journalArticle

Endogenous Retroviruses
Miniature Swine
Swine
Proviruses
Heterologous Transplantation