Photo of Linda Scobie

Linda Scobie

Professor

  • 70 Cowcaddens Road, Glasgow Caledonian University

    G4 0BA Glasgow

    United Kingdom

19952019
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Research Output 1995 2019

2019

Are there better assays to evaluate the risk of transmission of porcine endogenous retroviruses (PERVs) to human cells?

Denner, J. & Scobie, L., 29 Aug 2019, In : Xenotransplantation. 26, 4, 3 p., e12510.

Research output: Contribution to journalLetter

2018
7 Downloads (Pure)

Assessment of porcine endogenous retrovirus transmission across an alginate barrier used for the encapsulation of porcine islets

Crossan, C., Mourad, N. I., Smith, K., Gianello, P. & Scobie, L., Dec 2018, In : Xenotransplantation. 25, 6, e12409.

Research output: Contribution to journalArticle

Open Access
File
Endogenous Retroviruses
Swine
Testis
Cultured Cells
alginic acid
30 Downloads (Pure)

Cellular xenotransplantation of animal cells into people: benefits and risk

Scobie, L., Galli, C., Gianello, P., Cozzi, E. & Schuurman, H-J., 30 Apr 2018, Scientific and Technical Review. OIE, Vol. 37. p. 113-122

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Open Access
File
Heterologous Transplantation
Swine
Tissue and Organ Procurement
Safety
Animal Welfare
7 Downloads (Pure)

Examining the potential for porcine-derived islet cells to harbour viral pathogens

Crossan, C., O'Hara, Z., Mourad, N., Gianello, P. & Scobie, L., Apr 2018, In : Xenotransplantation. 25, 2, e12375.

Research output: Contribution to journalArticle

Open Access
File
Islets of Langerhans
Swine
Viruses
Newborn Animals
Hygiene
138 Downloads (Pure)
Open Access
File
Hepatitis E virus
Shellfish
shellfish
Scotland
supermarkets
86 Downloads (Pure)

Hepatitis E virus (HEV) in Scotland: evidence of recent increase in viral circulation in humans

Thom, K., Gilhooly, P., McGowan, K., Malloy, K., Jarvis, L. M., Crossan, C., Scobie, L., Blatchford, O., Smith-Palmer, A., Donnelly, M. C., Davidson, J. S., Johannessen, I., Simpson, K. J., Dalton, H. R. & Petrik, J., 22 Mar 2018, In : Eurosurveillance. 23, 12

Research output: Contribution to journalArticle

Open Access
File
Hepatitis E virus
Scotland
Seroepidemiologic Studies
Hepatitis E
Blood Donors
5 Downloads (Pure)

Is it currently possible to evaluate the risk posed by PERVs for clinical xenotransplantation?

Denner, J., Scobie, L. & Schuurman, H-J., 13 May 2018, In : Xenotransplantation. p. e12403

Research output: Contribution to journalComment/debate

Open Access
File
Heterologous Transplantation

PERVading strategies and infectious risk for clinical xenotransplantation

McGregor, C. G. A., Takeuchi, Y., Scobie, L. & Byrne, G., 18 Aug 2018, In : Xenotransplantation. 25, 4, p. e12402 3 p.

Research output: Contribution to journalComment/debate

Heterologous Transplantation

Theme issue on infections and safety – an introduction

Scobie, L. & Denner, J., 18 Aug 2018, In : Xenotransplantation. 25, 4, 15756802.

Research output: Contribution to journalComment/debate

Safety
Infection
31 Downloads (Pure)

Viral pathogens: what are they and do they matter?

Scobie, L., Crossan, C., Mourad, N. I., Galli, C., Perota, A. & Gianello, P., Jun 2018, In : Xenotransplantation.

Research output: Contribution to journalComment/debate

Open Access
File
2017
43 Downloads (Pure)

Characterization of porcine endogenous retrovirus expression in neonatal and adult pig pancreatic islets

Mourad, N. I., Crossan, C., Cruikshank, V., Scobie, L. & Gianello, P., Aug 2017, In : Xenotransplantation. 24, 4, e12311.

Research output: Contribution to journalArticle

Open Access
File
Endogenous Retroviruses
Islets of Langerhans
Swine
Pancreas
Heterologous Transplantation
34 Downloads (Pure)

Detection of viral hepatitis E in clinical liver biopsies

Prost, S., Crossan, C. L., Dalton, H. R., De Man, R. A., Kamar, N., Selves, J., Dhaliwal, C., Scobie, L. & Bellamy, C. O. C., Oct 2017, In : Histopathology. 71, 4, p. 580-590 11 p.

Research output: Contribution to journalArticle

Open Access
File
Hepatitis E
Hepatitis E virus
Biopsy
Polymerase Chain Reaction
Liver
16 Downloads (Pure)

Hepatitis E: a concise review of virology, epidemiology, clinical presentation and therapy

Donnelly, M. C., Scobie, L., Crossan, C. L., Dalton, H., Hayes, P. C. & Simpson, K. J., Jul 2017, In : Alimentary Pharmacology and Therapeutics. 46, 2, p. 126-141 16 p.

Research output: Contribution to journalArticle

Open Access
File
Hepatitis E
Virology
Epidemiology
Infection
Therapeutics
24 Downloads (Pure)

Posttransplant lymphoproliferative disorders in neuronal xenotransplanted macaques

Cavicchioli, L., Ferraresso, S., Westmoreland, S., Kaliyaperumal, S., Knight, H., Crossan, C., Scobie, L., Danesi, A., Vadori, M., Trez, D., Aron Badin, R., Hantraye, P. & Cozzi, E., Mar 2017, In : Veterinary Pathology. 54, 2

Research output: Contribution to journalArticle

Open Access
File
lymphatic diseases
Lymphoproliferative Disorders
Macaca
Lymphocryptovirus
Primates
2016
Heterologous Transplantation
Swine
Clinical Trials
Heterografts
Immunosuppressive Agents
Heterologous Transplantation
Type 1 Diabetes Mellitus
Swine
Clinical Trials
Endogenous Retroviruses

Selective CD28 antagonist blunts memory immune responses and promotes long-term control of skin inflammation in nonhuman primates

Poirier, N., Chevalier, M., Mary, C., Hervouet, J., Minault, D., Baker, P., Ville, S., Le Bas-Bernardet, S., Dilek, N., Belarif, L., Cassagnau, E., Scobie, L., Blancho, G. & Vanhove, B., 1 Jan 2016, In : Journal of Immunology. 196, 1, p. 274-283 10 p.

Research output: Contribution to journalArticle

Primates
Inflammation
T-Lymphocytes
Skin
Lymphocyte Count
2015
Plasma Exchange
Papio
Transferases
Heterografts
Swine

Correction: selective blockade of CD28-mediated T cell costimulation protects rhesus monkeys against acute fatal experimental autoimmune encephalomyelitis

Haanstra, K. G., Dijkman, K., Bashir, N., Bauer, J., Mary, C., Poirier, N., Baker, P., Crossan, C., Scobie, L., 't Hart, B. A. & Vanhove, B., 15 Jul 2015, In : Journal of Immunology. 195, 2

Research output: Contribution to journalArticle

Expression of recipient cytomegalovirus in immunosuppressed and xenotransplanted Macaca fascicularis may be related to more severe gastrointestinal lesions

Cavicchioli, L., Zanetti, R., Ferraresso, S., Crossan, C., Barry, P. A., Boldrin, M., Vadori, M., Ferro, S., Calabrese, F., Scobie, L., Cozzi, E. & Zappulli, V., Mar 2015, In : Xenotransplantation. 22, 2, p. 135–143 9 p.

Research output: Contribution to journalArticle

Heterologous Transplantation
Macaca fascicularis
Zoonoses
Cytomegalovirus
Primates

Hepatitis E virus and transfusion transmitted infection in Scotland

Scobie, L., Crossan, C., Davidson, J., Jarvis, L. & Simpson, K., Sep 2015, Journal of Clinical Virology: Abstracts of the 18th Annual Meeting of European Society for Clinical Virology, 9th–12th September 2015, Edinburgh. Elsevier B.V., Vol. 70. p. S124 1 p. (Journal of Clinical Virology; vol. 70, no. Supplement 1).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Hepatitis E virus
Scotland
Infection
Transplants
Seroepidemiologic Studies

Hepatitis E virus in patients with decompensated chronic liver disease: a prospective UK/French study

Blasco-Perrin, H., Madden, R. G., Stanley, A., Crossan, C., Hunter, J. G., Vine, L., Lane, K., Devooght-Johnson, N., Mclaughlin, C., Petrik, J., Stableforth, B., Hussaini, H., Phillips, M., Mansuy, J. M., Forrest, E., Izopet, J., Blatchford, O., Scobie, L., Peron, J. M. & Dalton, H. R., Sep 2015, In : Alimentary Pharmacology and Therapeutics. 42, 5, p. 574-581 8 p.

Research output: Contribution to journalArticle

Hepatitis E
Hepatitis E virus
Liver Diseases
Chronic Disease
Genotype

Is the increase in hepatitis E in Scotland true or a reflection of testing patterns?

Crossan, C. L., Nair, S., Gunson, R., Burns, J. P., Smith-Palmer, A., Johannessen, I., Ramalingam, S. & Scobie, L., Sep 2015, Journal of Clinical Virology: Abstracts of the 18th Annual Meeting of European Society for Clinical Virology, 9th–12th September 2015, Edinburgh. Elsevier B.V., Vol. 70. p. S96-97 2 p. (Journal of Clinical Virology; vol. 70, no. Supplement 1).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Hepatitis E
Scotland
Immunoglobulin G
Immunoglobulin M
RNA

Prevalence of hepatitis E virus in slaughter-age pigs in Scotland

Crossan, C., Grierson, S., Thomson, J., Ward, A., Nunez-Garcia, J., Banks, M. & Scobie, L., Jul 2015, In : Epidemiology and Infection. 143, 10, p. 2237-2240 4 p.

Research output: Contribution to journalArticle

Hepatitis E virus
Scotland
Swine
Serum
RNA

Selective blockade of CD28-mediated T cell costimulation protects rhesus monkeys against acute fatal experimental autoimmune encephalomyelitis

Haanstra, K. G., Dijkman, K., Bashir, N., Bauer, J., Mary, C., Poirier, N., Baker, P., Scobie, L., ’t Hart, B. A. & Vanhove, B., Feb 2015, In : Journal of Immunology. 194, 4, p. 1454-1466 13 p.

Research output: Contribution to journalArticle

Autoimmune Experimental Encephalomyelitis
Macaca mulatta
T-Lymphocytes
Regulatory T-Lymphocytes
Placebos

Unusual serological response to hepatitis E virus in plasma donors consistent with re-infection

Baylis, S. A., Crossan, C., Corman, V. M., Blumel, J., Scobie, L. & Dalton, H. R., Nov 2015, In : Vox Sanguinis. 109, 4, p. 406-409 4 p.

Research output: Contribution to journalArticle

Hepatitis E virus
Infection
Immunoglobulin M
Immunoglobulin G
2014

Antibiotic susceptibility and resistance of Staphylococcus aureus isolated from fresh porcine skin xenografts: risk to recipients with thermal injury

Busby, S-A., Robb, A., Lang, S., Takeuchi, Y., Vesely, P. & Scobie, L., Mar 2014, In : Burns. 40, 2, p. 288-294 7 p.

Research output: Contribution to journalArticle

Zoonoses
Microbial Drug Resistance
Heterografts
Staphylococcus aureus
Swine

Hepatitis E virus in patients with acute severe liver injury

Crossan, C., Simpson, K. J., Craig, D. G., Bellamy, C., Davidson, J., Dalton, H. & Scobie, L., Jun 2014, In : world journal of hepatology. 6, 6, p. 426-434 9 p.

Research output: Contribution to journalArticle

Hepatitis E virus
Hepatitis E
Liver
Wounds and Injuries
Immunoglobulin G

The International Xenotransplantation Association consensus statement on conditions for undertaking clinical trials of xenocorneal transplantation

Kim, M. K., Choi, H. J., Kwon, I., Pierson, R. N., Cooper, D. K. C., Soulillou, J-P., O'Connell, P. J., Vabres, B., Maeda, N., Hara, H., Scobie, L., Gianello, P., Takeuchi, Y., Yamada, K., Hwang, E-S., Kim, S. J. & Park, C-G., Oct 2014, In : Xenotransplantation. 21, 5, p. 420-430 11 p.

Research output: Contribution to journalArticle

Heterologous Transplantation
Transplantation
Clinical Trials
Guidelines
Ethical Review
2013

Hepatitis E: source and route of infection, clinical manifestations and new developments

Scobie, L. & Dalton, H., Jan 2013, In : Journal of Viral Hepatitis. 20, 1, p. 1-11 11 p.

Research output: Contribution to journalArticle

Hepatitis E
Infection
Zoonoses
Developed Countries
Hepatitis

Hepatitis E seroprevalence in recipients of renal transplants or haemodialysis in southwest England: a case-control study

Harrison, A., Scobie, L., Crossan, C., Parry, R., Johnston, P., Stratton, J., Dickinson, S., Ellis, V., Hunter, J. G., Prescott, O. R., Madden, R., Lin, N. X., Henley, W. E., Bendall, R. P. & Dalton, H., Feb 2013, In : Journal of Medical Virology. 85, 2, p. 266-271 6 p.

Research output: Contribution to journalArticle

Hepatitis E
Seroepidemiologic Studies
England
Renal Dialysis
Case-Control Studies

Hepatitis E virus and porcine-derived heparin

Crossan, C., Scobie, L., Godwin, J., Hunter, J. G., Hawkes, T. & Dalton, H., Apr 2013, In : Emerging Infectious Diseases. 19, 4, p. 686-688 3 p.

Research output: Contribution to journalLetter

Hepatitis E
Hepatitis E virus
Heparin
Swine
Meat Products

Hepatitis E virus in Scottish blood donors

Cleland, A., Smith, L., Crossan, C., Blatchford, O., Dalton, H., Scobie, L. & Petrik, J., 2013, In : Vox Sanguinis.

Research output: Contribution to journalArticle

Hepatitis E virus
Blood Donors
Seroepidemiologic Studies
Blood Transfusion
RNA

Long-term IgG response to porcine Neu5Gc antigens without transmission of PERV in burn patients treated with porcine skin xenografts

Scobie, L., Padler-Karavani, V., Le Bas-Bernardet, S., Crossan, C., Blaha, J., Matouskova, M., Hector, R. D., Cozzi, E., Vanhove, B., Charreau, B., Blancho, G., Bourdais, L., Tallacchini, M., Ribes, J. M., Yu, H., Chen, X., Kracikova, J., Broz, L., Hejnar, J., Vesely, P. & 3 others, Takeuchi, Y., Varki, A. & Soulillou, J-P., Sep 2013, In : Journal of Immunology. 191, 6, p. 2907-2915 9 p.

Research output: Contribution to journalArticle

Endogenous Retroviruses
Heterografts
Swine
Immunoglobulin G
Antigens

Suggestions for the diagnosis and elimination of hepatitis E virus in pigs used for xenotransplantation

Busby, S., Crossan, C., Godwin, J., Petersen, B., Galli, C., Cozzi, E., Takeuchi, Y. & Scobie, L., Jun 2013, In : Xenotransplantation. 20, 3, p. 188–192 5 p.

Research output: Contribution to journalArticle

Hepatitis E virus
Heterologous Transplantation
Swine
Zoonoses
Virus Diseases

The role of DNA methylation in expression and transmission of porcine endogenous retrovirus

Scobie, L., Nov 2013, In : Journal of Virology. 87, 22, p. 12110-12120 11 p.

Research output: Contribution to journalArticle

Retroviridae
Endogenous Retroviruses
DNA methylation
DNA Methylation
Swine
2012

Analyses of pig genomes provide insight into porcine demography and evolution

Nov 2012, In : Nature. 491, 7424, p. 393–398 7 p.

Research output: Contribution to journalArticle

demography
swine
genome
Duroc
Sus scrofa

Hepatitis E virus genotype 3 in shellfish, United Kingdom

Crossan, C., Baker, P., Craft, J., Yasu, T., Dalton, H. & Scobie, L., Dec 2012, In : Emerging Infectious Diseases. 18, 12, p. 2085-2087 2 p.

Research output: Contribution to journalLetter

Hepatitis E virus
Shellfish
Manure
Bivalvia
Genotype

Potential zoonotic infection of porcine endogenous retrovirus in xenotransplantation

Mattiuzzo, G., Takeuchi, Y. & Scobie, L., 2012, Xenotransplantation : Methods in Molecular Biology. Costa, C. & Máñez, R. (eds.). Humana Press, p. 263-279 16 p. (Methods in Molecular Biology ).

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Endogenous Retroviruses
Heterologous Transplantation
Zoonoses
Swine
Retroviridae Infections

Xenotransplantation-associated infectious risk: a WHO consultation

Jay A., F., Scobie, L. & Takeuchi, Y., Apr 2012, In : Xenotransplantation. 19, 2, p. 72-81 10 p.

Research output: Contribution to journalArticle

Heterologous Transplantation
Referral and Consultation
Swine
Communicable Diseases
Endogenous Retroviruses
2011

Detection of porcine endogenous retrovirus (PERV) viremia in diseased versus healthy US pigs by qualitative and quantitative Real-Time RT-PCR

Pal, N., Baker, R., Schalk, S., Scobie, L., Tucker, A. W. & Opriessnig, T., 1 Mar 2011, In : Transboundary and Emerging Diseases.

Research output: Contribution to journalArticle

Retroviridae
Endogenous Retroviruses
Viremia
viremia
Real-Time Polymerase Chain Reaction

First xenotransplantations of galactosyl-transferase knock-out, CD55, CD59, CD39 AND, fucosyl-transferase transgenic pig kidneys into baboons

Le Bas-Bernardet, S., Tillou, X., Poirier, N., Dilek, N., Chatelais, M., Devallière, J., Charreau, B., Minault, D., Crossan, C. & Scobie, L., 1 Jan 2011, In : Transplantation Proceedings.

Research output: Contribution to journalArticle

Heterologous Transplantation
Papio
Transferases
Swine
Kidney

Microbial safety in xenotransplantation

Nicolas J., M., Yasuhiro, T., Giada, M. & Scobie, L., Apr 2011, In : Current Opinion in Organ Transplantation. 16, 2, p. 201-206 6 p.

Research output: Contribution to journalArticle

Heterologous Transplantation
Swine
Safety
Viruses
Endogenous Retroviruses

Porcine endogenous retroviruses in xenotransplantation

Scobie, L. & Garkavenko, O., 1 Jan 2011, The Minipig in Biomedical Research. CRC Press

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

regulatory authority
pharmacology
pharmaceutical industry
animal
welfare

Retroviruses

Scobie, L. & Tucker, A. W., 1 Jan 2011, Diseases of Swine. John Wiley & Sons

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Retroviridae
Animal Welfare
Virus Diseases
Physical Examination
Communicable Diseases

Xenotransplantation: methods and protocols

Mattiuzzo, G., Takeuchi, Y. & Scobie, L., 1 Jan 2011, Methods in Molecular Biology. Humana Press

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

2010

Porcine pathogens and xenotransplantation: PERV and beyond!

Scobie, L., 1 Jan 2010, In : Xenotransplantation. 17, p. 94-120 27 p.

Research output: Contribution to journalArticle

Endogenous Retroviruses
Heterologous Transplantation
Swine
Viruses
Zoonoses

Uptake of synthetic Low Density Lipoprotein by leukemic stem cells: a potential stem cell targeted drug delivery strategy

Zhou, P., Hatziieremia, S., Elliott, M. A., Scobie, L., Crossan, C., Michie, A. M., Holyoake, T. L., Halbert, G. W. & Jørgensen, H. G., 1 Dec 2010, In : Journal of Controlled Release. 148, 3, p. 380-387 8 p.

Research output: Contribution to journalArticle

LDL Lipoproteins
Stem Cells
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Pharmaceutical Preparations
Myeloid Progenitor Cells
2009

A novel model of SCID-X1 reconstitution reveals predisposition to retrovirus-induced lymphoma but no evidence of ¿C gene oncogenicity

Scobie, L., Hector, R., Grant, L., Bell, M., Neilsen, A. A., Meikle, S., Philbey, A. & Thrasher, A. J., 1 Mar 2009, In : Molecular Therapy. 17, 6, p. 1031-1038 8 p.

Research output: Contribution to journalArticle

Retroviridae
Lymphoma
X-Linked Combined Immunodeficiency Diseases
Locus Control Region
Cytokine Receptors

Assessment of the potential risk of infection associated with Clostridium difficile from porcine xenografts

Bakri, M. M., Sutherland, A. D., Brown, D. J., Vesely, P., Crossan, C. & Scobie, L., 1 Dec 2009, In : Xenotransplantation. 16, 6, p. 472-476 5 p.

Research output: Contribution to journalArticle

Clostridium difficile
Heterografts
Heterologous Transplantation
Swine
Zoonoses