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  • 70 Cowcaddens Road, Glasgow Caledonian University

    G4 0BA Glasgow

    United Kingdom

20042022

Research activity per year

Personal profile

Research interests

Gillian received her first degree in Genetics from the University of Glasgow, which incorporated an industrial work placement year in Astrazeneca, Cheshire. She then carried out her PhD at the Institute of Psychiatry, Kings College London where she was involved in a multi-national collaborative study to identify novel genetic risk factors for Alzheimer’s disease. Following the award of her doctorate (2005), she was awarded a fellowship from the Alzheimer’s Research Trust and moved to the University of Oxford to develop a new molecular method based on infectious bacterial artificial chromosomes (iBACs) that allowed the functional analyses of disease-associated genetic variation. She was then awarded a fellowship from the Alzheimer’s Society (2008) and moved to the University of Edinburgh to expand her research on Alzheimer’s disease candidate genes using the iBAC technology. In 2011, she initiated work on spinal muscular atrophy (SMA). She is primarily interested in identifying novel molecular mechanisms suitable for the development of therapeutic intervention and expanding the evidence for a multi-system involvement in SMA pathogenesis. She joined Glasgow Caledonian University as a Lecturer in 2015.

External positions

Member, Euan MacDonald Centre, University of Edinburgh

1 Aug 2015 → …

Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

  1. SDG 3 - Good Health and Well-being
    SDG 3 Good Health and Well-being

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Collaborations and top research areas from the last five years

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  • Microvasculopathy in spinal muscular atrophy is driven by a reversible autonomous endothelial cell defect

    Zhou, H., Hong, Y., Scoto, M., Thomson, A., Pead, E., MacGillivray, T., Hernandez-Gerez, E., Catapano, F., Meng, J., Zhang, Q., Hunter, G., Shorrock, H. K., Ng, T. K., Hamida, A., Sanson, M., Baranello, G., Howell, K., Gillingwater, T. H., Brogan, P. & Thompson, D. A. & 2 others, Parson, S. H. & Muntoni, F., 1 Nov 2022, In: Journal of Clinical Investigation. 132, 21, e153430.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    File
    21 Citations (Scopus)
    107 Downloads (Pure)
  • Restoration of SMN in Schwann cells reverses myelination defects and improves neuromuscular function in spinal muscular atrophy

    Hunter, G., Powis, R. A., Jones, R. A., Groen, E. J. N., Shorrock, H. K., Lane, F. M., Zheng, Y., Sherman, D. L., Brophy, P. J. & Gillingwater, T. H., 1 Jul 2016, In: Human Molecular Genetics. 25, 13, p. 2853-2861 9 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    File
    35 Citations (Scopus)
    4468 Downloads (Pure)
  • Systemic restoration of UBA1 ameliorates disease in spinal muscular atrophy

    Powis, R. A., Karyka, E., Boyd, P., Come, J., Jones, R. A., Zheng, Y., Szunyogova, E., Groen, E. J. N., Hunter, G., Thomson, D., Wishart, T. M., Becker, C. G., Parson, S. H., Martinat, C., Azzouz, M. & Gillingwater, T. H., 21 Jul 2016, In: JCI Insight. 1, 11, e87908.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    File
    77 Citations (Scopus)
    225 Downloads (Pure)
  • Alleles that increase risk for type 2 diabetes mellitus are not associated with increased risk for Alzheimer's disease

    Proitsi, P., Lupton, M. K., Velayudhan, L., Hunter, G., Newhouse, S., Lin, K., Fogh, I., Tsolaki, M., Daniilidou, M., Pritchard, M., Craig, D., Todd, S., Johnston, J. A., McGuinness, B., Kloszewska, I., Soininen, H., Mecocci, P., Vellas, B., Passmore, P. A. & Sims, R. & 6 others, Williams, J., Brayne, C., Stewart, R., Sham, P., Lovestone, S. & Powell, J. F., Dec 2014, In: Neurobiology of Aging. 35, 12, p. 2883.e3-2883.e10 8 p.

    Research output: Contribution to journalArticlepeer-review

    9 Citations (Scopus)
  • Dysregulation of ubiquitin homeostasis and β-catenin signaling promote spinal muscular atrophy

    Wishart, T. M., Mutsaers, C. A., Reissland, M., Reimer, M. M., Hunter, G., Hannam, M. L., Eaton, S. L., Fuller, H. R., Roche, S. L., Somers, E., Morse, R., Young, P. J., Lamont, D. J., Hammerschmidt, M., Joshi, A., Hohenstein, P., Morris, G. E., Parson, S. H., Skehel, P. A. & Becker, T. & 4 others, Robinson, I. M., Becker, C. G., Wirth, B. & Gillingwater, T. H., 1 Apr 2014, In: Journal of Clinical Investigation. 124, 4, p. 1821-1834 14 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    File
    158 Citations (Scopus)
    336 Downloads (Pure)