No photo of Gillian Hunter

Gillian Hunter

Dr.

  • 70 Cowcaddens Road, Glasgow Caledonian University

    G4 0BA Glasgow

    United Kingdom

20042016
If you made any changes in Pure these will be visible here soon.

Personal profile

Research interests

Gillian received her first degree in Genetics from the University of Glasgow, which incorporated an industrial work placement year in Astrazeneca, Cheshire. She then carried out her PhD at the Institute of Psychiatry, Kings College London where she was involved in a multi-national collaborative study to identify novel genetic risk factors for Alzheimer’s disease. Following the award of her doctorate (2005), she was awarded a fellowship from the Alzheimer’s Research Trust and moved to the University of Oxford to develop a new molecular method based on infectious bacterial artificial chromosomes (iBACs) that allowed the functional analyses of disease-associated genetic variation. She was then awarded a fellowship from the Alzheimer’s Society (2008) and moved to the University of Edinburgh to expand her research on Alzheimer’s disease candidate genes using the iBAC technology. In 2011, she initiated work on spinal muscular atrophy (SMA). She is primarily interested in identifying novel molecular mechanisms suitable for the development of therapeutic intervention and expanding the evidence for a multi-system involvement in SMA pathogenesis. She joined Glasgow Caledonian University as a Lecturer in 2015.

External positions

Member

1 Aug 2015 → …

Fingerprint Dive into the research topics where Gillian Hunter is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

Alzheimer Disease Medicine & Life Sciences
Spinal Muscular Atrophy Medicine & Life Sciences
Genes Medicine & Life Sciences
Motor Neurons Medicine & Life Sciences
Single Nucleotide Polymorphism Medicine & Life Sciences
Chromosomes, Human, Pair 10 Medicine & Life Sciences
Haplotypes Medicine & Life Sciences
Schwann Cells Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Research Output 2004 2016

75 Downloads (Pure)

Restoration of SMN in Schwann cells reverses myelination defects and improves neuromuscular function in spinal muscular atrophy

Hunter, G., Powis, R. A., Jones, R. A., Groen, E. J. N., Shorrock, H. K., Lane, F. M., Zheng, Y., Sherman, D. L., Brophy, P. J. & Gillingwater, T. H., 1 Jul 2016, In : Human Molecular Genetics. 25, 13, p. 2853-2861 9 p.

Research output: Contribution to journalArticle

Open Access
File
Spinal Muscular Atrophy
Schwann Cells
Neuroglia
Motor Neurons
Pathology
56 Downloads (Pure)

Systemic restoration of UBA1 ameliorates disease in spinal muscular atrophy

Powis, R. A., Karyka, E., Boyd, P., Come, J., Jones, R. A., Zheng, Y., Szunyogova, E., Groen, E. JN., Hunter, G., Thomson, D., Wishart, T. M., Becker, C. G., Parson, S. H., Martinat, C., Azzouz, M. & Gillingwater, T. H., 21 Jul 2016, In : JCI Insight. 1, 11, 17 p., e87908.

Research output: Contribution to journalArticle

Open Access
File
Spinal Muscular Atrophy
Motor Neurons
Ubiquitin
Dependovirus
Zebrafish

Alleles that increase risk for type 2 diabetes mellitus are not associated with increased risk for Alzheimer's disease

Proitsi, P., Lupton, M. K., Velayudhan, L., Hunter, G., Newhouse, S., Lin, K., Fogh, I., Tsolaki, M., Daniilidou, M., Pritchard, M., Craig, D., Todd, S., Johnston, J. A., McGuinness, B., Kloszewska, I., Soininen, H., Mecocci, P., Vellas, B., Passmore, P. A., Sims, R. & 6 others, Williams, J., Brayne, C., Stewart, R., Sham, P., Lovestone, S. & Powell, J. F., Dec 2014, In : Neurobiology of Aging. 35, 12, p. 2883.e3-2883.e10 8 p.

Research output: Contribution to journalArticle

Type 2 Diabetes Mellitus
Alzheimer Disease
Alleles
Genotype
Odds Ratio
116 Downloads (Pure)

Dysregulation of ubiquitin homeostasis and ß-catenin signalling promote spinal muscular atrophy

Wishart, T., Mutsaers, C., Reissland, M., Reimer, M., Hunter, G., Hannam, M., Eaton, S., Fuller, H., Roche, S., Somers, E., Morse, R., Young, P., Lamont, D., Hammerschmidt, M., Joshi, A., Hohenstein, P., Morris, G., Parson, S., Skehel, P., Becker, T. & 4 others, Robinson, I., Becker, C., Wirth, B. & Gillingwater, T., Mar 2014, In : Journal of Clinical Investigation. 124, 4, p. 1821-1834 14 p.

Research output: Contribution to journalArticle

Open Access
File
Spinal Muscular Atrophy
Catenins
Ubiquitin
Homeostasis
Pathology

Increased levels of UCHL1 are a compensatory response to disrupted ubiquitin homeostasis in spinal muscular atrophy and do not represent a viable therapeutic target

Powis, R., Mutsaers, C., Wishart, T., Hunter, G., Wirth, B. & Gillingwater, T., Dec 2014, In : Neuropathology and Applied Neurobiology. 40, 7, p. 873-887 15 p.

Research output: Contribution to journalArticle

Spinal Muscular Atrophy
Hydrolases
Ubiquitin
Homeostasis
Therapeutics