Projects per year
Personal profile
Research interests
Gillian received her first degree in Genetics from the University of Glasgow, which incorporated an industrial work placement year in Astrazeneca, Cheshire. She then carried out her PhD at the Institute of Psychiatry, Kings College London where she was involved in a multi-national collaborative study to identify novel genetic risk factors for Alzheimer’s disease. Following the award of her doctorate (2005), she was awarded a fellowship from the Alzheimer’s Research Trust and moved to the University of Oxford to develop a new molecular method based on infectious bacterial artificial chromosomes (iBACs) that allowed the functional analyses of disease-associated genetic variation. She was then awarded a fellowship from the Alzheimer’s Society (2008) and moved to the University of Edinburgh to expand her research on Alzheimer’s disease candidate genes using the iBAC technology. In 2011, she initiated work on spinal muscular atrophy (SMA). She is primarily interested in identifying novel molecular mechanisms suitable for the development of therapeutic intervention and expanding the evidence for a multi-system involvement in SMA pathogenesis. She joined Glasgow Caledonian University as a Lecturer in 2015.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
External positions
Member, Euan MacDonald Centre, University of Edinburgh
1 Aug 2015 → …
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Collaborations and top research areas from the last five years
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Uncovering novel effectors of Nrf2 dysregulation in the progression of Alzheimer's Disease
Kerr, F. (PI), Hunter, G. (CoI) & Wray, S. (CoI)
1/03/20 → 30/09/20
Project: Research Grant
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Is histone ubiquitination altered in Alzheimer's disease?
Hunter, G. (PI) & Kerr, F. (CoI)
1/06/19 → 13/05/22
Project: Research Grant
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Pilot grant - Neural crest cell development in spinal muscular atrophy.
Hunter, G. (PI)
1/10/17 → 30/09/18
Project: Research Grant
Research output
- 37 Article
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Microvasculopathy in spinal muscular atrophy is driven by a reversible autonomous endothelial cell defect
Zhou, H., Hong, Y., Scoto, M., Thomson, A., Pead, E., MacGillivray, T., Hernandez-Gerez, E., Catapano, F., Meng, J., Zhang, Q., Hunter, G., Shorrock, H. K., Ng, T. K., Hamida, A., Sanson, M., Baranello, G., Howell, K., Gillingwater, T. H., Brogan, P. & Thompson, D. A. & 2 others, , 1 Nov 2022, In: Journal of Clinical Investigation. 132, 21, e153430.Research output: Contribution to journal › Article › peer-review
Open AccessFile5 Citations (Scopus)21 Downloads (Pure) -
Restoration of SMN in Schwann cells reverses myelination defects and improves neuromuscular function in spinal muscular atrophy
Hunter, G., Powis, R. A., Jones, R. A., Groen, E. J. N., Shorrock, H. K., Lane, F. M., Zheng, Y., Sherman, D. L., Brophy, P. J. & Gillingwater, T. H., 1 Jul 2016, In: Human Molecular Genetics. 25, 13, p. 2853-2861 9 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile32 Citations (Scopus)4426 Downloads (Pure) -
Systemic restoration of UBA1 ameliorates disease in spinal muscular atrophy
Powis, R. A., Karyka, E., Boyd, P., Come, J., Jones, R. A., Zheng, Y., Szunyogova, E., Groen, E. J. N., Hunter, G., Thomson, D., Wishart, T. M., Becker, C. G., Parson, S. H., Martinat, C., Azzouz, M. & Gillingwater, T. H., 21 Jul 2016, In: JCI Insight. 1, 11, e87908.Research output: Contribution to journal › Article › peer-review
Open AccessFile69 Citations (Scopus)189 Downloads (Pure) -
Alleles that increase risk for type 2 diabetes mellitus are not associated with increased risk for Alzheimer's disease
Proitsi, P., Lupton, M. K., Velayudhan, L., Hunter, G., Newhouse, S., Lin, K., Fogh, I., Tsolaki, M., Daniilidou, M., Pritchard, M., Craig, D., Todd, S., Johnston, J. A., McGuinness, B., Kloszewska, I., Soininen, H., Mecocci, P., Vellas, B., Passmore, P. A. & Sims, R. & 6 others, , Dec 2014, In: Neurobiology of Aging. 35, 12, p. 2883.e3-2883.e10 8 p.Research output: Contribution to journal › Article › peer-review
9 Citations (Scopus) -
Dysregulation of ubiquitin homeostasis and β-catenin signaling promote spinal muscular atrophy
Wishart, T. M., Mutsaers, C. A., Reissland, M., Reimer, M. M., Hunter, G., Hannam, M. L., Eaton, S. L., Fuller, H. R., Roche, S. L., Somers, E., Morse, R., Young, P. J., Lamont, D. J., Hammerschmidt, M., Joshi, A., Hohenstein, P., Morris, G. E., Parson, S. H., Skehel, P. A. & Becker, T. & 4 others, , 1 Apr 2014, In: Journal of Clinical Investigation. 124, 4, p. 1821-1834 14 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile147 Citations (Scopus)205 Downloads (Pure)