Projects per year
Personal profile
Research interests
Gillian received her first degree in Genetics from the University of Glasgow, which incorporated an industrial work placement year in Astrazeneca, Cheshire. She then carried out her PhD at the Institute of Psychiatry, Kings College London where she was involved in a multi-national collaborative study to identify novel genetic risk factors for Alzheimer’s disease. Following the award of her doctorate (2005), she was awarded a fellowship from the Alzheimer’s Research Trust and moved to the University of Oxford to develop a new molecular method based on infectious bacterial artificial chromosomes (iBACs) that allowed the functional analyses of disease-associated genetic variation. She was then awarded a fellowship from the Alzheimer’s Society (2008) and moved to the University of Edinburgh to expand her research on Alzheimer’s disease candidate genes using the iBAC technology. In 2011, she initiated work on spinal muscular atrophy (SMA). She is primarily interested in identifying novel molecular mechanisms suitable for the development of therapeutic intervention and expanding the evidence for a multi-system involvement in SMA pathogenesis. She joined Glasgow Caledonian University as a Lecturer in 2015.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
External positions
Member, Euan MacDonald Centre, University of Edinburgh
1 Aug 2015 → …
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Uncovering novel effectors of Nrf2 dysregulation in the progression of Alzheimer's Disease
Kerr, F., Hunter, G. & Wray, S.
1/03/20 → 30/09/20
Project: Research Grant
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Is histone ubiquitination altered in Alzheimer's disease?
Hunter, G. & Kerr, F.
1/06/19 → 13/05/22
Project: Research Grant
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Pilot grant - Neural crest cell development in spinal muscular atrophy.
1/10/17 → 30/09/18
Project: Research Grant
Research output
- 36 Article
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Restoration of SMN in Schwann cells reverses myelination defects and improves neuromuscular function in spinal muscular atrophy
Hunter, G., Powis, R. A., Jones, R. A., Groen, E. J. N., Shorrock, H. K., Lane, F. M., Zheng, Y., Sherman, D. L., Brophy, P. J. & Gillingwater, T. H., 1 Jul 2016, In: Human Molecular Genetics. 25, 13, p. 2853-2861 9 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile26 Citations (Scopus)150 Downloads (Pure) -
Systemic restoration of UBA1 ameliorates disease in spinal muscular atrophy
Powis, R. A., Karyka, E., Boyd, P., Come, J., Jones, R. A., Zheng, Y., Szunyogova, E., Groen, E. J. N., Hunter, G., Thomson, D., Wishart, T. M., Becker, C. G., Parson, S. H., Martinat, C., Azzouz, M. & Gillingwater, T. H., 21 Jul 2016, In: JCI Insight. 1, 11, e87908.Research output: Contribution to journal › Article › peer-review
Open AccessFile53 Citations (Scopus)128 Downloads (Pure) -
Alleles that increase risk for type 2 diabetes mellitus are not associated with increased risk for Alzheimer's disease
Proitsi, P., Lupton, M. K., Velayudhan, L., Hunter, G., Newhouse, S., Lin, K., Fogh, I., Tsolaki, M., Daniilidou, M., Pritchard, M., Craig, D., Todd, S., Johnston, J. A., McGuinness, B., Kloszewska, I., Soininen, H., Mecocci, P., Vellas, B., Passmore, P. A., Sims, R., & 6 others , Dec 2014, In: Neurobiology of Aging. 35, 12, p. 2883.e3-2883.e10 8 p.Research output: Contribution to journal › Article › peer-review
9 Citations (Scopus) -
Dysregulation of ubiquitin homeostasis and β-catenin signaling promote spinal muscular atrophy
Wishart, T. M., Mutsaers, C. A., Reissland, M., Reimer, M. M., Hunter, G., Hannam, M. L., Eaton, S. L., Fuller, H. R., Roche, S. L., Somers, E., Morse, R., Young, P. J., Lamont, D. J., Hammerschmidt, M., Joshi, A., Hohenstein, P., Morris, G. E., Parson, S. H., Skehel, P. A., Becker, T., & 4 others , 3 Mar 2014, In: Journal of Clinical Investigation. 124, 4, p. 1821-1834 14 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile134 Citations (Scopus)172 Downloads (Pure) -
Increased levels of UCHL1 are a compensatory response to disrupted ubiquitin homeostasis in spinal muscular atrophy and do not represent a viable therapeutic target
Powis, R., Mutsaers, C., Wishart, T., Hunter, G., Wirth, B. & Gillingwater, T., Dec 2014, In: Neuropathology and Applied Neurobiology. 40, 7, p. 873-887 15 p.Research output: Contribution to journal › Article › peer-review
23 Citations (Scopus)