Photo of Fiona Kerr
  • 70 Cowcaddens Road, Glasgow Caledonian University

    G4 0BA Glasgow

    United Kingdom

20042018
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Research Output 2004 2018

2018
11 Downloads (Pure)

Molecular mechanisms of lithium action: switching the light on multiple targets for dementia using animal models

Kerr, F., Bjedov, I. & Sofola-Adesakin, O., 28 Aug 2018, In : Frontiers in Molecular Neuroscience. 11

Research output: Contribution to journalArticle

Open Access
File
Lithium
Dementia
Animal Models
Light
Glycogen Synthase Kinase 3
2017
44 Downloads (Pure)

Direct Keap1-Nrf2 disruption as a potential therapeutic target for Alzheimer’s disease

Kerr, F., Sofola-Adesakin, O., Ivanov, D. K., Gatliff, J., Perez-Nievas, B. G., Bertrand, H. C., Martinez, P., Callard, R., Snoeren, I., Cocheme, H. M., Adcott, J., Khericha, M., Castillo-Quan, J. I., Wells, G., Noble, W., Thornton, J. & Partridge, L., 2 Mar 2017, In : PLoS Genetics. 13, 3

Research output: Contribution to journalArticle

Open Access
File
Alzheimer disease
Alzheimer Disease
toxicity
therapeutics
inhibitor
53 Downloads (Pure)

Reduced insulin signaling maintains electrical transmission in a neural circuit in aging flies

Augustin, H., McGourty, K., Allen, M. J., Madem, S. K., Adcot, J., Kerr, F., Wong, C. T., Vincent, A., Godenschwege, T., Boucrot, E. & Partridge, L., 13 Sep 2017, In : PLoS Biology. 15, 9, p. e2001655

Research output: Contribution to journalArticle

Open Access
File
synaptic transmission
gap junctions
Gap Junctions
Diptera
Recycling
2016

Deletion of endogenous Tau proteins is not detrimental in Drosophila

Burnouf, S., Grönke, S., Augustin, H., Dols, J., Gorsky, M. K., Werner, J., Kerr, F., Alic, N., Martinez, P. & Partridge, L., 15 Mar 2016, In : Scientific Reports. 6

Research output: Contribution to journalArticle

Open Access
tau Proteins
Diptera
Drosophila
Alzheimer Disease
Intrinsically Disordered Proteins
35 Downloads (Pure)

Increased glucose transport into neurons rescues Aß toxicity in Drosophila

Niccoli, T., Cabecinha, M., Tillmann, A., Kerr, F., Wong, C. T., Cardenes, D., Vincent, A. J., Bettedi, L., Li, L., Gronke, S., Dols, J. & Partridge, L., Sep 2016, In : Current Biology. 26, 18, p. R806-R809 4 p.

Research output: Contribution to journalArticle

Open Access
File
Drosophila
Neurons
Toxicity
Alzheimer disease
neurons
6 Downloads (Pure)

Lithium promotes longevity through GSK3/NRF2-dependent hormesis

Castillo-Quan, J. I., Li, L., Kinghorn, K. J., Ivanov, D. K., Tain, L. S., Slack, C., Kerr, F., Nespital, T., Thornton, J., Hardy, J., Bjedov, I. & Partridge, L., Apr 2016, In : Cell Reports. 15, 3, p. 638–650 13 p.

Research output: Contribution to journalArticle

Open Access
File
Hormesis
Lithium
Glycogen Synthase Kinase 3
NF-E2 Transcription Factor
Aging of materials
2014

A holidic medium for Drosophila melanogaster

Piper, M. D. W., Blanc, E., Leitão-Gonçalves, R., Yang, M., He, X., Linford, N. J., Hoddinott, M. P., Hopfen, C., Soultoukis, G. A., Niemeyer, C., Kerr, F., Pletcher, S. D., Ribeiro, C. & Partridge, L., 1 Jan 2014, In : Nature Methods. 11, 1

Research output: Contribution to journalArticle

Open Access
Nutrition
Drosophila melanogaster
Diet
Food
Diptera
2012

Ageing increases vulnerability to aß42 toxicity in Drosophila

Rogers, I., Kerr, F., Martinez, P., Hardy, J., Lovestone, S. & Partridge, L., 12 Jul 2012, In : PLoS ONE . 7, 7

Research output: Contribution to journalArticle

Drosophila
Toxicity
Diptera
Aging of materials
toxicity
2011

Dietary restriction delays aging, but not neuronal dysfunction, in Drosophila models of Alzheimer's disease

Kerr, F., Augustin, H., Piper, M. D. W., Gandy, C., Allen, M. J., Lovestone, S. & Partridge, L., 1 Nov 2011, In : Neurobiology of Aging. 32, 11, p. 1977–1989 13 p.

Research output: Contribution to journalArticle

Open Access
Drosophila
Alzheimer Disease
Diptera
Molecular Pathology
Genetic Predisposition to Disease
2010

Inhibition of GSK-3 ameliorates Abeta pathology in an adult-onset Drosophila model of Alzheimer's disease

Sofola, O., Kerr, F., Rogers, I., Killick, R., Augustin, H., Gandy, C., Allen, M. J., Hardy, J., Lovestone, S. & Partridge, L., 2 Sep 2010, In : PLoS Genetics. 6, 9

Research output: Contribution to journalArticle

Open Access
Glycogen Synthase Kinase 3
Alzheimer disease
pathology
Drosophila
Alzheimer Disease

Mechanisms of life span extension by rapamycin in the fruit fly Drosophila melanogaster

Bjedov, I., Toivonen, J. M., Kerr, F., Slack, C., Jacobson, J., Foley, A. & Partridge, L., 5 Jan 2010, In : Cell Metabolism. 11, 1

Research output: Contribution to journalArticle

Open Access
Sirolimus
Life Expectancy
Drosophila melanogaster
Diptera
Fruit
2009

Deletion of Irs2 reduces amyloid deposition and rescues behavioural deficits in APP transgenic mice

Killick, R., Scales, G., Leroy, K., Causevic, M., Hooper, C., Irvine, E. E., Choudhury, A. I., Drinkwater, L., Kerr, F., Al-Qassab, H., Stephenson, J., Yilmaz, Z., Giese, K. P., Brion, J-P., Withers, D. J. & Lovestone, S., 14 Aug 2009, In : Biochemical and Biophysical Research Communications. 386, 1, p. 257–262 6 p.

Research output: Contribution to journalArticle

Open Access
Phosphorylation
Amyloid beta-Protein Precursor
Amyloid
Transgenic Mice
Insulin Receptor Substrate Proteins
2007

Hyperphosphorylation of tau and neurofilaments and activation of CDK5 and ERK1/2 in PTEN-deficient cerebella

Nayeem, N., Kerr, F., Naumann, H., Linehan, J., Lovestone, S. & Brandner, S., 5 Jan 2007, In : Molecular and Cellular Neuroscience. 34, 3, p. 400-408 9 p.

Research output: Contribution to journalArticle

Intermediate Filaments
Cerebellum
Ganglioneuroma
Neurons
Mutation
2006

PTEN, a negative regulator of PI3 kinase signalling, alters tau phosphorylation in cells by mechanisms independent of GSK-3

Kerr, F., Rickle, A., Nayeem, N., Brandner, S., Cowburn, R. F. & Lovestone, S., 29 May 2006, In : FEBS Letters. 580, 13

Research output: Contribution to journalArticle

Open Access
Glycogen Synthase Kinase 3
Phosphorylation
Phosphatidylinositol 3-Kinases
Phosphoric Monoester Hydrolases
Alzheimer Disease
2005

School students as Drosophila experimenters

Siyad, F., Griffiths, J., Janjua, F., Jackson, E., Rodrigues, I., Kerr, F., Mackay, D. & Lovestone, S., 12 Jul 2005, In : PLoS Biology. 3, 7

Research output: Contribution to journalArticle

Open Access
Drosophila
students
Glycogen Synthase Kinase 3
Students
Phenotype
2004

Glycogen synthase kinase-3 is increased in white cells early in Alzheimer's disease

Hye, A., Kerr, F., Archer, N., Foy, C., Poppe, M., Brown, R., Hamilton, G., Powell, J., Anderton, B. & Lovestone, S., 13 Dec 2004, In : Neuroscience Letters. 373, 1, p. 1-4 4 p.

Research output: Contribution to journalArticle

Glycogen Synthase Kinase 3
Alzheimer Disease
Serine
Protein Isoforms
Proteins