Photo of Fiona Kerr
  • 70 Cowcaddens Road, Glasgow Caledonian University

    G4 0BA Glasgow

    United Kingdom

20042018
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Personal profile

Research interests

Biography

  • Research Fellow, Glasgow Caledonian University, 2017-present
  • Lecturer in Biomedical Sciences, Edinburgh Napier University, 2016-2017
  • Postdoctoral Research Associate (Alzheimer’s Research UK), Institute of Healthy Ageing,  University College London, 2009-2017
  • Postdoctoral Research Associate (EU-FP7, AddNeuroMed Project), Institute of Healthy Ageing, University College London, 2006-2009
  • PhD (Lloyds Charities Trust/Alzheimer’s Research Trust PhD Scholarship), Kings College London, 2002-2006
  • Research Technician (Eisai London Research Laboratories), 2000-2002
  • BSc Pharmacology (Hons with Work Placement at AstraZeneca) University of Glasgow, 2000

 

Research overview

Alzheimer’s disease (AD) is the leading cause of dementia in humans, affecting families across all communities. As our population grows older this poses a significant challenge for future generations, since current therapies do not slow-down the progression of memory loss in dementia patients. A priority area for AD research is therefore to develop new drugs to halt the disease, by finding ways to protect neurons as pathology progresses.

 

My current interest is in understanding the molecular mechanisms by which the ageing process increases neuronal vulnerability to AD pathology, using Drosophila and human induced pluripotent stem cell (hiPSC) neuron models of disease. By targeting ageing, a common risk factor for many neurodegenerative diseases, my work aims to deliver potential new targets for the development of therapies to maintain neuronal integrity in AD and, potentially, other neurological conditions. 

External positions

Lecturer in Biomedical Sciences, Edinburgh Napier University

11 Jul 201611 Jul 2017

Fingerprint Dive into the research topics where Fiona Kerr is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

Glycogen Synthase Kinase 3 Medicine & Life Sciences
Drosophila Medicine & Life Sciences
Alzheimer Disease Medicine & Life Sciences
Diptera Medicine & Life Sciences
Alzheimer disease Agriculture & Biology
Phosphorylation Chemical Compounds
Lithium Medicine & Life Sciences
Drosophila melanogaster Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Research Output 2004 2018

10 Downloads (Pure)

Molecular mechanisms of lithium action: switching the light on multiple targets for dementia using animal models

Kerr, F., Bjedov, I. & Sofola-Adesakin, O., 28 Aug 2018, In : Frontiers in Molecular Neuroscience. 11

Research output: Contribution to journalArticle

Open Access
File
Lithium
Dementia
Animal Models
Light
Glycogen Synthase Kinase 3
43 Downloads (Pure)

Direct Keap1-Nrf2 disruption as a potential therapeutic target for Alzheimer’s disease

Kerr, F., Sofola-Adesakin, O., Ivanov, D. K., Gatliff, J., Perez-Nievas, B. G., Bertrand, H. C., Martinez, P., Callard, R., Snoeren, I., Cocheme, H. M., Adcott, J., Khericha, M., Castillo-Quan, J. I., Wells, G., Noble, W., Thornton, J. & Partridge, L., 2 Mar 2017, In : PLoS Genetics. 13, 3

Research output: Contribution to journalArticle

Open Access
File
Alzheimer disease
Alzheimer Disease
toxicity
therapeutics
inhibitor
53 Downloads (Pure)

Reduced insulin signaling maintains electrical transmission in a neural circuit in aging flies

Augustin, H., McGourty, K., Allen, M. J., Madem, S. K., Adcot, J., Kerr, F., Wong, C. T., Vincent, A., Godenschwege, T., Boucrot, E. & Partridge, L., 13 Sep 2017, In : PLoS Biology. 15, 9, p. e2001655

Research output: Contribution to journalArticle

Open Access
File
synaptic transmission
gap junctions
Gap Junctions
Diptera
Recycling

Deletion of endogenous Tau proteins is not detrimental in Drosophila

Burnouf, S., Grönke, S., Augustin, H., Dols, J., Gorsky, M. K., Werner, J., Kerr, F., Alic, N., Martinez, P. & Partridge, L., 15 Mar 2016, In : Scientific Reports. 6

Research output: Contribution to journalArticle

Open Access
tau Proteins
Diptera
Drosophila
Alzheimer Disease
Intrinsically Disordered Proteins
35 Downloads (Pure)

Increased glucose transport into neurons rescues Aß toxicity in Drosophila

Niccoli, T., Cabecinha, M., Tillmann, A., Kerr, F., Wong, C. T., Cardenes, D., Vincent, A. J., Bettedi, L., Li, L., Gronke, S., Dols, J. & Partridge, L., Sep 2016, In : Current Biology. 26, 18, p. R806-R809 4 p.

Research output: Contribution to journalArticle

Open Access
File
Drosophila
Neurons
Toxicity
Alzheimer disease
neurons