Candida auris exhibits resilient biofilm characteristics in vitro: implications for environmental persistence

Research output: Contribution to journalArticle

Published

DOI

  • Bryn Short
  • Jason Brown
  • Christopher Delaney
  • Leighann Sherry
  • Craig Williams
  • Gordon Ramage
  • Ryan Kean

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Original languageEnglish
Pages (from-to)92-96
Number of pages5
JournalJournal of Hospital Infection
Volume103
Issue number1
Early online date18 Jun 2019
DOIs
StatePublished - Sep 2019

Abstract

Surfaces within healthcare play a key role in the transmission of drug-resistant
pathogens. Candida auris is an emerging multi-drug resistant yeast which has the ability to survive for prolonged periods on environmental surfaces. Here we show that the ability to form cellular aggregates increases survival after 14 days, which coincides with the upregulation of biofilm-associated genes. Additionally, the aggregating strain demonstrated tolerance to clinical concentrations of sodium hypochlorite and remain viable 14 days’ post treatment. The ability of C. auris to adhere and persist on environmental surfaces emphasises our need to better understand the biology of this fungal pathogen.

Keywords

  • Candida auris, disinfection, surface, biofilm